ArticleContemporary clinical dentistry
Prognostic Significance of Genetic Polymorphisms rs3819024 (A/G) of Interleukin-17A Gene and rs763780 (C/T) of Interleukin-17F Gene in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: Oral submucous fibrosis (OSMF) is an oral potentially malignant disorder characterized by progressive scarring disorder affecting the submucosa of the panoral mucous membrane. It has a high risk of malignant transformation. Aims: This study aims to identify the possible association of rs3819024 (A/G) of interleukin ( Settings and Design: One hundred OSMF patients and 50 OSCC patients as cases and 100 healthy individuals as control subjects were selected based on inclusion and exclusion criteria from the outpatient department of the dental college and hospital in Kolkata. Methods: Deoxyribonucleic acid (DNA) was extracted with the phenol-chloroform-isoamyl alcohol method. Genotyping was done by polymerase chain reaction (PCR). These PCR products were subjected to restriction fragment length polymorphism analysis following restriction enzyme digestion to determine the type of polymorphism. The digested DNA was then separated and analyzed using agarose gel electrophoresis. Quantitative genotypic data and the disease risk were evaluated by the odds ratio and confidence interval analysis. Statistical Analysis Used: Chi-square association test. Results: Single-nucleotide polymorphisms rs3819024 (A/G) polymorphism of the Conclusions: Mutated allele G of rs3819024 may act as a protective allele, while the mutated C allele of rs763780 may act as a risk allele for the development of OSMF and malignant conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.