ArticleFrontiers in nutrition2025
Vitamin D deficiency and risk of acute kidney injury after ischemic stroke: a propensity-matched cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association between serum zinc levels and new-onset hypertension: A 5-year retrospective cohort study.Medicine · 2026Article
- Vitamin D Signaling in Neurodegenerative Disorders: Mechanisms, Therapeutic Potential, and Clinical Implications.Nutrients · 2026Review
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Vitamin D deficiency (VDD) has been linked to adverse outcomes in various clinical settings, but its relationship with post-stroke acute kidney injury (AKI) remains unexplored. Methods: This retrospective cohort study utilized the TriNetX research network database to identify adult patients with first-documented ischemic stroke between January 2010 and December 2024. Patients were stratified based on serum 25-hydroxyvitamin D levels measured within 6 weeks pre-stroke: VDD group (<20 ng/mL) and control group (≥30 ng/mL). After 1:1 propensity score matching, we compared 30-day and 1-12 month outcomes between groups, with the primary outcome being AKI incidence within 30 days post-stroke. Results: After matching ( Conclusion: Pre-stroke VDD is associated with increased risk of post-stroke AKI and other adverse outcomes. The observed dose-dependent relationship suggests potential benefits from optimizing vitamin D status. These findings highlight the importance of assessing vitamin D levels in stroke risk stratification and suggest potential preventive strategies.
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