Evidence map›Paper›PMID 41561177›Full record

Trial reportFrontiers in nutrition2025

Clinical benefits of

Mageswaran Uma Mageswary, Pin Li, Rocky Vester Richmond, Yusof Azianey, Intan Juliana Abd Hamid, Fahisham Taib, Min-Tze Liong, Adli Ali, Joo Shun Tan, Yumei Zhang

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05794815 (Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05794815 naunknown statusnot on this map

Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms

TypeinterventionalSponsorMin-Tze LIONGRan2023 to 2026Enrolled120ConditionsRespiratory Infection (for Example, Pneumonia, Bronchitis)ArmsProbiotic, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ZipStrain Enables Rapid and Precise Strain-Resolved Metagenomics.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mageswaran Uma MageswarySchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Pin LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.
Rocky Vester RichmondDepartment of Pediatrics, Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Yusof AzianeyKepala Batas Health Clinic, Kepala Batas, Pulau Pinang, Malaysia.
Intan Juliana Abd HamidDepartment of Clinical Medicine, Advanced Medical & Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Penang, Malaysia.
Fahisham TaibPaediatric Department, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Min-Tze LiongSchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Adli AliDepartment of Pediatrics, Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Joo Shun TanSchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The early-life gut microbiota is critical for immune development and long-term health, and plays an essential role in the digestion and metabolism of dietary components, including human milk oligosaccharides (HMOs). Probiotic supplementation is a promising strategy to modulate this ecosystem and prevent common childhood infectious illnesses, though strain-specific effects require further investigation. Method: This 12-week, double-blind, randomized, placebo-controlled trial evaluated the efficacy of Result: Probiotic supplementation significantly reduced the incidence of respiratory problems as compared to the placebo group (Week 12: 15.0 vs. 42.4%, Conclusion: Clinical trial registration: https://clinicaltrials.gov/study/NCT05794815?term=NCT05794815&rank=1, identifier number: NCT05794815.

Indexed as

Bifidobacterium infantis YLGB-1496childrengut microbiotaprobioticrandomized controlled trialrespiratory tract infections

Identifiers

PMID41561177
PMCPMC12812959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.