ArticleFrontiers in cellular and infection microbiology2025
Zoliflodacin inhibits
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Biofilm-FormingPlants (Basel, Switzerland) · 2026Article
- Automation of Polysaccharide Quantification: A Rapid High-Throughput Assay Enabled by Liquid Handling Technology.Biotech (Basel (Switzerland)) · 2026Article
- A biomimetic urchin-like photothermal nanoplatform for the efficient eradication ofFrontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Zoliflodacin (ZFD) is a new type of antibiotic whose anticaries potential through controlling biofilms remains unknown. This study aimed to explore the effects of ZFD on the conditional formation of cariogenic Methods: Crystal violet analysis, colony forming unit (CFU) counting, and MTT assays were used to determine biofilm biomass, viable bacterial cell counts, and bacterial metabolic viability, respectively, while acid generation by biofilms was monitored by measuring pH and lactic acid production. The anthrone-sulfuric acid method and polysaccharide/bacterial staining were used to investigate extracellular polysaccharide (EPS) production. The microstructure of Results: We found ZFD significantly inhibited Conclusions: In summary, ZFD is a potential antibacterial agent for caries control because of its antibiofilm effects, inconspicuous cytotoxicity, low risk of resistance induction and antibacterial activity against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.