ArticleFrontiers in endocrinology2025
Dietary medium chain triglycerides impairs orexigenic action of ghrelin in mice.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Ghrelin, a stomach-derived hormone, increases food intake and body weight. Efforts have been made therefore to modulate ghrelin signaling for the treatment of obesity or emaciation. However, basic biology of the potential effects of dietary nutrients on ghrelin action has not yet been fully uncovered. Methods: To investigate an impact of fat intake on orexigenic effect of ghrelin, we examined ghrelin transgenic mice or mice treated with ghrelin fed with the diet containing medium-chain triglycerides (MCT). Results: Five-day MCT diet feeding increased plasma ghrelin levels by 2.5-fold compared with long-chain triglyceride (LCT)-fed mice, potentially through Discussion: Our results provide evidence for the MCT-induced attenuation of the orexigenic effect of ghrelin, and suggest a novel interplay between dietary lipids and hormone signaling.
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