ArticleFrontiers in endocrinology2025
Effect of type 2 diabetes mellitus on sperm quality and outcomes of assisted reproductive techniques in infertile male patients.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetes mellitus (DM) is one of the most common endocrine disorders affecting various physiological systems and tissues, including the reproductive organs in men. However, the consequences of DM for male individuals undergoing assisted reproductive technology (ART) remain unclear. Objective: To investigate the sperm quality and the outcomes of Methods: We retrospectively analyzed data from 318 infertile couples for IVF/ICSI cycle outcomes. The experimental group included 106 infertile couples (with male partners all diagnosed with T2DM) who underwent ART treatment at our center. The negative control group consisted of 212 non-diabetic infertile couples, matched by male/female body mass index (BMI) (± 1 kg/m²), male/female age (± 2 years), and serum anti-Müllerian hormone (AMH) levels (± 2 ng/mL). Patients were categorized into two groups based on clinical pregnancy. The χ² test and logistic regression analysis were used to identify and determine the influencing factors of clinical pregnancy. Results: Infertile men with T2DM had significantly lower sperm volume (2.4 ± 2.2 vs. 2.7 ± 1.2, P < 0.01) and significantly decreased sperm motility compared to the control group (23.0 ± 17.2 vs. 29.7 ± 15.3, P < 0.01). In IVF/ICSI cycles, both groups exhibited similar results in two-pronuclear (2PN) fertilization rates and high-grade embryo rates ( Conclusion: T2DM in infertile men exerts adverse effects on sperm quality; however, the decline in sperm quality did not translate into compromised clinical ART outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.