ArticleFrontiers in endocrinology2025
Bone turnover markers (β-CTX, PINP, ALP) in osteoporosis: correlation with bone loss and fracture risk stratification.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Efficacy and safety of denosumab, zoledronic acid and alendronate on bone mineral density and trabecular bone score in men with osteoporosis.Age and ageing · 2026Trial
- Protein acylation and bone metabolism: bidirectional crosstalk linking metabolic reprogramming to skeletal homeostasis.Journal of molecular histology · 2026Review
- Plant-Based Functional Custard Enriched with Vitamin DFoods (Basel, Switzerland) · 2026Article
- Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders.World journal of experimental medicine · 2026Review
- The FGF23/α-Klotho Axis in Postmenopausal Osteoporosis: Associations with Bone Mineral Density and Diagnostic Discrimination.Journal of clinical medicine · 2026Article
- Tracking Bone Loss in GLP-1RA Therapy: The Potential of the Deoxypyridinoline Urine Test.Diagnostics (Basel, Switzerland) · 2026Article
- Biomarkers of Inflammaging and Cellular Senescence in Musculoskeletal (MSK) Diseases: The Knowns and the Unknowns.Biomedicines · 2026Article
- A multiparameter model (OsteoSC-M3) for early detection and risk stratification of osteoporosis in women: a multicentre cohort study in China.EClinicalMedicine · 2026Article
- Nutritional Biomarkers, Bone Turnover, and Oxidative DNA Damage in Postmenopausal Women with Periodontitis: A Cross-Sectional Study.Nutrients · 2026Article
- The endocrine pathway during whole body vibration modulates the immune system and the osteogenesis in postmenopausal women with osteoporosis.Frontiers in endocrinology · 2026Article
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6 authors.
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Abstract
Objective: To investigate the correlation of β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type I N-terminal propeptide (PINP), alkaline phosphatase (ALP) with bone mineral density (BMD) in patients with osteoporosis and evaluate their predictive value for secondary fracture risk. Methods: A total of 180 osteoporosis patients and 80 healthy controls were enrolled. The osteoporosis group was stratified into fracture and non-fracture cohorts. Correlation of β-CTX, PINP, ALP with BMD at lumbar spine (L1-4) and femoral neck was assessed using Pearson correlation coefficient. Binary logistic regression model was employed to analyze the risk factors associated with secondary fractures in patients with osteoporosis and receiver-operator characteristic (ROC) curve was used for assessing the predictive utility. Results: Osteoporosis patients exhibited significantly higher β-CTX, PINP, and ALP levels compared to controls (all Conclusion: Elevated β-CTX, PINP, and ALP levels correlate with reduced BMD and independently predict secondary fracture risk in osteoporosis patients. Integrating these biomarkers with BMD enhances fracture risk stratification, supporting their inclusion in clinical risk assessment tool.
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