Evidence map›Paper›PMID 41560889›Full record

ArticleNeurobiology of stress2026

Developmental and early-life stress-induced effects on 5-HT

James T Moore, Matthew J Sunthimer, Ethan White, Jeffrey G Mellott, Merri J Rosen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

James T MooreHearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Matthew J SunthimerHearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Ethan WhiteHearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Jeffrey G MellottHearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Merri J RosenHearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.

Funding

Auditory Processing Deficits in Early-Onset Conductive Hearing LossR01DC013314 · NIDCD · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ROSEN, MERRI J. · 2014 to 2024
$4.1M
Age-related GABAergic loss in the central auditory circuitsR01DC017708 · NIDCD · NORTHEAST OHIO MEDICAL UNIVERSITY · PI MELLOTT, JEFFREY GARRETT · 2020 to 2024
$1.7M
Cortical processing of informational maskingR01DC019126 · NIDCD · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI SHINN-CUNNINGHAM, BARBARA · 2020 to 2025
$1.3M
NIDCD NIH HHS R01 DC013314NIDCD NIH HHS R01 DC017708NIDCD NIH HHS R01 DC019126
6 · The paper itself

Abstract

Early life stress (ELS) is a well-known predictor of neuropsychiatric disease and contributes to the development of sensory processing deficits that persist throughout life. Organisms are particularly susceptible to the deleterious effects of stress during critical periods, when neuroplasticity is heightened, and initial representations of the sensory environment are mapped to cortex. When ELS is induced during the auditory cortical (ACx) critical period, it impairs both neural and behavioral responses to a variety of auditory stimuli that rely on temporal processing. Mechanisms by which ELS may alter critical period plasticity are of particular interest in understanding ELS-related pathology, including the 5-HT3R interneuron system, which has been implicated in regulating neural activity during critical periods. Here we examined two principal subpopulations of interneurons in primary ACx: VIP and NDNF cells, which account for a majority of cortical neurons expressing 5-HT3R. The expression of the Htr3a gene during normal development and under ELS conditions was quantified using multiplex fluorescent

Indexed as

5-HT3RAdversityAuditory cortexCritical periodDevelopmentEarly-life stressInhibitionLayer 1Serotonin

Identifiers

PMID41560889
PMCPMC12814090

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.