ArticleFrontiers in veterinary science2025
Reproductive efficacy of a modified-live porcine reproductive and respiratory syndrome vaccine against Korean PRRSV-2 challenge in sows.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evaluation of the reproductive efficacy of a modified-live vaccine (MLV) based on porcine reproductive and respiratory syndrome virus-2 (PRRSV-2). Objective: The objective of this study was to evaluate the efficacy of a MLV based on porcine PRRSV-2 against a heterologous Korean PRRSV-2 lineage 1 strain challenge in pregnant sows. Animals: Twelve pregnant sows from PRRSV-free farms were randomly assigned to three groups (four sows per group). Methods: Sows in the vaccinated-challenged group received a 2.0 mL intramuscular dose of PRRSV-2 MLV and were subsequently challenged intranasally with a heterologous PRRSV-2 strain. Results: Vaccinated-challenged sows improved reproductive performance, including a higher number of live-born piglets and fewer stillbirths compared with unvaccinated-challenged sows. Viral genomic loads were lower in vaccinated-challenged sows and their offspring as well. Vaccinated-challenged sows also elicited a significantly higher frequency of PRRSV-2 specific interferon- Discussion: These findings demonstrated that the PRRSV-2 MLV administered to pregnant sows provide protection against heterologous challenge through clinical, virological, and immunological evaluation.
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