Evidence map›Paper›PMID 41560831›Full record

ArticleMaterials today. Bio2026

Bioconvergence of sound-guided and supramolecular assembly strategies to create peptide-protein composite hydrogels with predictable shape-to-function features.

Cosimo Ligorio, Alessandro Cianciosi, Riccardo Tognato, Micaela Natta, Romedi Parolini, Sena Ardicli, Huseyn Babayev, Ieva Sapjanskaite, Samantha L Kilgour, Richard Homer and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cosimo LigorioBiodiscovery Institute, University of Nottingham, Nottingham, UK.
Alessandro CianciosiAO Research Institute Davos, Switzerland.
Riccardo TognatoAO Research Institute Davos, Switzerland.
Micaela NattaAO Research Institute Davos, Switzerland.
Romedi ParoliniAO Research Institute Davos, Switzerland.
Sena ArdicliSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Huseyn BabayevSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Ieva SapjanskaiteSchool of Pharmacy, University of Nottingham, Nottingham, UK.
Samantha L KilgourSchool of Chemistry, University of Nottingham, Nottingham, UK.
Richard HomerWolfson Building, University of Nottingham, Nottingham, UK.
Bapan PramanikSchool of Pharmacy, University of Nottingham, Nottingham, UK.
Zhiyu ZhouInnovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopaedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Andrea MalandrinoJohannes Kepler University Linz, Kepler University Hospital, Department for Orthopaedics and Traumatology, Linz, Austria.
Eleni PriglingerJohannes Kepler University Linz, Kepler University Hospital, Department for Orthopaedics and Traumatology, Linz, Austria.
Cezmi AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Martin J StoddartAO Research Institute Davos, Switzerland.
Alvaro MataBiodiscovery Institute, University of Nottingham, Nottingham, UK.
Tiziano SerraAO Research Institute Davos, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purely protein-based hydrogels are widely used in tissue engineering for their biomimicry and biocompatibility, yet remain challenging to tailor with precision and predictability at biological and mechanical levels. To overcome this, synthetic self-assembling peptide amphiphiles (PAs) offer opportunities for supramolecular customization, both as single-phase materials and co-assembled with proteins to create hybrid nanocomposites with emerging functionalities. Similarly, contactless, sound-guided bioassembly techniques using liquid-phase hydrogel precursors are emerging as strategic tools for obtaining structured and functional hydrogels. Leveraging these advances, here a fast, contactless, 'one-pot' bioassembly strategy merging supramolecular PA self-assembly with sound-guided patterning to fabricate hybrid peptide-protein hydrogels with predictable, shape-dependent functionality is presented. Using fibrin as proof-of-concept, material performance is biologically enhanced by incorporating growth factor-binding PAs, while inorganic microparticles are embedded and spatially organized

Indexed as

BiofabricationBottom-upCompositeMultiscalePeptide amphiphilesProteinsSound-based bioassembly

Identifiers

PMID41560831
PMCPMC12813217

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.