Evidence map›Paper›PMID 41560821›Full record

ArticleMaterials today. Bio2026

ROS-responsive hydrogel loaded with capsaicin promotes tenogenic differentiation of tendon stem/progenitor cells and enhances tendon injury repair.

Yun-Liang Zhu, Si-Chao Gu, Bao-Liang Lu, Hu Sun, Zai-Yong Guan, Rui-Hua Zhou, Ting-Yong Sun, Wen Gao, Shi-Yuan Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yun-Liang ZhuDepartment of Orthopedics, Gaoyou People's Hospital, The Third Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225600, China.
Si-Chao GuDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Bao-Liang LuDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Hu SunDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Zai-Yong GuanDepartment of Orthopedics, Gaoyou People's Hospital, The Third Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225600, China.
Rui-Hua ZhouDepartment of Orthopedics, Gaoyou People's Hospital, The Third Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225600, China.
Ting-Yong SunDepartment of Orthopedics, Gaoyou People's Hospital, The Third Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225600, China.
Wen GaoDepartment of Orthopedics, Gaoyou People's Hospital, The Third Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225600, China.
Shi-Yuan FangDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon injury repair remains challenging in sports medicine and orthopedics, partly due to limited endogenous regenerative capacity and sustained low-grade inflammation, which disrupt tendon stem/progenitor cells (TSPCs) homeostasis, impairing tenogenesis and enhancing osteogenesis, leading to complications like heterotopic ossification. Here, we engineered a reactive oxygen species (ROS)-responsive hydrogel loaded with capsaicin (CGT) and explored its role in tendon regeneration.

Indexed as

BiomaterialsCapsaicinInflammationTendon injuryTendon stem/progenitor cells

Identifiers

PMID41560821
PMCPMC12813339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.