Evidence map›Paper›PMID 41560818›Full record

ArticleMaterials today. Bio2026

Genetically engineered bacteria with jacketed biofilm for enhancing drug delivery into tumor.

Aiqing Ma, Jiaxing Wang, Weijian Song, Jiahua Pu, Xiaoyuan Cai, Weijing Han, Yuanyuan Wang, Hong Pan, Jiacheng Ouyang, Senbin Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aiqing MaGuangdong Provincial Key Laboratory of Natural Drugs Research and Development, The Second Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Jiaxing WangGuangdong Provincial Key Laboratory of Natural Drugs Research and Development, The Second Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Weijian SongState Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Jiahua PuState Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiaoyuan CaiGuangdong Provincial Key Laboratory of Natural Drugs Research and Development, The Second Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Weijing HanSongshan Lake Materials Laboratory, Dongguan, 523808, Guangdong, China.
Yuanyuan WangState Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Hong PanGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China.
Jiacheng OuyangGuangdong Provincial Key Laboratory of Natural Drugs Research and Development, The Second Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Senbin WuSongshan Lake Materials Laboratory, Dongguan, 523808, Guangdong, China.
Rourong ChenStomatological Center, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong province, China.
Fang FangGuangdong Provincial Key Laboratory of Natural Drugs Research and Development, The Second Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China.
Fei YanState Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-targeted bacteria have emerged as promising drug carriers due to their intrinsic motility and hypoxia-homing property. Therapeutic agents can be loaded onto the bacterial surface, enabling their active delivery into tumor tissues. However, premature drug release during systemic circulation-likely triggered by various physiological/physical factors-inevitably results in reduced efficacy or increased off-target toxicity. Here, we present a genetic engineering strategy that enables

Indexed as

Drug deliveryJacketed-biofilm bacteriaLive bacterial carriersPhotothermal therapyTumor penetration

Identifiers

PMID41560818
PMCPMC12813058

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.