Evidence map›Paper›PMID 41560817›Full record

ArticleMaterials today. Bio2026

Polystyrene nanoplastics-induced lung epithelial cells ferroptosis promotes pulmonary fibrosis via YY1/FTL axis.

Wenxia Bu, Yueyuan Jin, Yifan Zhou, Fengxu Wang, Dongnan Zheng, Rongzhu Liu, Xuehai Wang, Mengjiao Yu, Shan Bao, Rui Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wenxia BuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Yueyuan JinDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Yifan ZhouDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Fengxu WangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Dongnan ZhengDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Rongzhu LiuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Xuehai WangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Mengjiao YuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Shan BaoChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China.
Rui ZhaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Jinlong LiSchool of Public Health, North China University of Science and Technology, Tangshan, Hebei, 06321, China.
Xiaoyu ZhouDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Jian FengDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Xinyuan ZhaoDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.
Demin ChengDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoplastics (NPs) have emerged as pervasive environmental pollutants, and polystyrene nanoplastics (PS-NPs) have been increasingly implicated in pulmonary toxicity and fibrosis. Here, we established both an in vitro BEAS-2B bronchial epithelial injury model and an in vivo mouse model by repeated oropharyngeal aspiration of PS-NPs. We observed pronounced pulmonary fibrosis and ferroptotic death of alveolar type II cells. Integrated transcriptomic and proteomic profiling highlighted enrichment of the ferroptosis pathway, and in vitro and in vivo experiments confirmed that PS-NPs suppress GPX4 while inducing FTL, thereby driving lipid peroxidation. Mechanistically, YY1 binds the FTL promoter to repress its expression, and YY1 knockdown alleviates ferroptosis and fibrosis. Our findings identify YY1/FTL-mediated ferroptosis as a key mechanism by which PS-NPs induce pulmonary fibrosis.

Indexed as

FerroptosisFTLPolystyrene nanoplasticsPulmonary fibrosisYY1

Identifiers

PMID41560817
PMCPMC12813319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.