Evidence map›Paper›PMID 41560810›Full record

ArticleMaterials today. Bio2026

A multifunctional hyaluronic acid hydrogel with pH-responsive metformin release for accelerated healing of diabetic infected wounds.

Zexiang Zheng, Xing Yang, Xinshuo Liu, Li Xu, Lihua Li, Jinhuan Tian, Changren Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zexiang ZhengEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Xing YangEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Xinshuo LiuEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Li XuEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Lihua LiEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Jinhuan TianEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.
Changren ZhouEngineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou, 511443, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds remain a global public-health threat due to simultaneous bleeding, bacterial colonization and persistent inflammation. We hypothesized that a dynamic metal-polyphenol hydrogel that instantly seals bleeding vessels, acid-triggered releases metformin and synergistically photothermal antibacterial would break this deadlock. Therefore, we developed a multifunctional hyaluronic acid hydrogel (ODF-Met) by conjugating metformin to dopamine-grafted oxidized hyaluronic acid via dynamic imine bonds, followed by coordination with Fe

Indexed as

Diabetic infected woundHyaluronic acid hydrogelMetforminPhotothermal antibacterialpH-responsive release

Identifiers

PMID41560810
PMCPMC12813348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.