ReviewMaterials today. Bio2026
Immunomodulatory role of decellularized extracellular matrix in skin wound healing.
Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Metal organic framework based synergistic improvement of hypoxia for optimizing diabetic wounds healing.Materials today. Bio · 2026Article
- Optimised cryopreservation preserves functional competence of goat adipose-derived mesenchymal stem cells and is associated with stress-adapted mitochondrial and paracrine features.Journal of tissue engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix (ECM) plays a pivotal role in skin wound healing by providing structural support and biochemical signals that regulate cellular behavior. Recent studies highlight the immunomodulatory properties of decellularized ECM (dECM), particularly its influence on macrophage polarization and the overall immune response, which are critical for effective tissue repair. During wound healing, macrophages transition from a pro-inflammatory to an anti-inflammatory phenotype, a process crucial for regulating angiogenesis, fibroblast proliferation, and tissue remodeling. Numerous studies have demonstrated that incorporating dECM into skin wound healing significantly enhances therapeutic outcomes by accelerating this phenotypic shift and fostering the transition to an anti-inflammatory environment. Furthermore, the decellularization process, which removes cellular components while preserving the ECM's biochemical and physical properties, has enabled the development of advanced scaffolds, hydrogels, and bioinks for biomedical applications. Despite these promising findings, the precise mechanisms underlying ECM-driven immune modulation remain unclear, limiting its full therapeutic potential of dECM in wound healing. This review summarizes current progress in ECM processing, applications, and immunological mechanisms in wound healing, with a particular focus on ECM-macrophage interactions. Additionally, it discusses future strategies for optimizing ECM-based, immunomodulation-driven approaches to wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.