Evidence map›Paper›PMID 41560790›Full record

ArticleMaterials today. Bio2026

Hydrogels Targeting Mechanical-biological signaling transitions of interleukin-33 alleviates intervertebral-disc degeneration.

Jiancheng Zheng, Xingkai Zhang, Fangke Zhang, Mingyu Zhao, Lei Wang, Tao Han, Feifei Pu, Yazhou Lin, Man Liu, Xiangdong Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiancheng ZhengDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Xingkai ZhangDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Fangke ZhangDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Mingyu ZhaoLaboratory of Molecular Biology, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.
Lei WangClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, 453000, China.
Tao HanClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, 453000, China.
Feifei PuDepartment of Orthopedics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yazhou LinDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Man LiuLaboratory of Molecular Biology, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.
Xiangdong ZhangLaboratory of Molecular Biology, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.
Fei WangDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Zhe ChenDepartment of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Jitian LiClinical Medical Center of Tissue Engineering and Regeneration, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang, 453000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical-biological signaling transitions (MBSTs) cause intervertebral-disc degeneration (IVDD). The key to MBSTs lies in nucleus pulposus cells (NPCs), but it is not yet fully understood, and relevant therapeutic targets and strategies are lacking. In this study, we found that the key mechanobiological-signaling factor interleukin-33 (IL-33) played an important role in stress-induced IVDD through a piezo-type mechanosensitive ion channel component 1 (PIEZO1)-mediated positive-feedback loop. Specifically, analysis of clinical samples showed that IL-33 was significantly upregulated in NPCs from IVDD patients and that compressive-stress stimulation further enhanced IL-33 expression via the PIEZO1 pathway, thereby accelerating disc degeneration. To discover the underlying mechanism, we fabricated the transfection nanoparticles formed by benzoboric acid-modified polyethyleneimine (PEI-PBA) with

Indexed as

GelMA hydrogelInterleukin-33Intervertebral-disc degenerationNucleus pulposus cellsPolyethyleneimine nanoparticles

Identifiers

PMID41560790
PMCPMC12813325

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.