Human donor islets coated with functionalized chitosan and alginate nanoscale layers can restore normoglycemia in diabetic mice.

Michael Yilma Yitayew, Ling Li, Masaya Oshima, Raphael Scharfmann, Maryam Tabrizian

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Michael Yilma YitayewDepartment of Biomedical Engineering, McGill University, Montréal, QC, Canada.

Ling LiDepartment of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada.

Masaya OshimaUniversité Paris Cité, Institut Cochin, CNRS, INSERM U1016, Paris, 75014, France.

Raphael ScharfmannUniversité Paris Cité, Institut Cochin, CNRS, INSERM U1016, Paris, 75014, France.

Maryam TabrizianDepartment of Biomedical Engineering, McGill University, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conformal coating is a promising encapsulation approach to reduce the immunogenicity of islet transplants in the treatment of type 1 diabetes (T1D). The primary objective of this work was to investigate a combination of non-immunogenic polyelectrolytes, tetrahydropyran triazole phenyl-alginate (TZ-AL) and quaternized phosphocholine-chitosan (PC-QCH), to create a nano-thin film onto the surface of human donor islets and assess its potential for clinical translation. To evaluate the coating materials, spheroids made from human-derived proliferative EndoC-βH1 and non-proliferative βH5 beta cell lines as pseudo-islet models was used as complementary models before applying the coating onto human islets. Coating formation and biocompatibility were first validated with spheroids and then applied to human islets. The results indicated formation of the desired coating morphology on both spheroids and human islets. In addition, both coated spheroids and human islets cultured for 7 days

Indexed as

Beta cellsConformal coatingIslet transplantationLayer-by-layerNano encapsulationT1D

Identifiers

PMID41560789

DOI10.1016/j.mtbio.2026.102761

PMCPMC12813323

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.