SynthesisFrontiers in pharmacology2025
A critical review of systematic reviews and meta-analyses of curcumin for knee osteoarthritis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Curcumin Between Pleiotropic Potential and Translational Constraints.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to assess the efficacy of curcumins in treating knee osteoarthritis (KOA). Methods: We performed a comprehensive review of literature from inception to 11 January 2025, identifying all systematic reviews (SRs) and meta-analyses (MAs) on curcumin treatment for KOA. Two independent reviewers conducted literature screening and data extraction. Evaluation of methodological and reporting quality, risk of bias, evidence quality, and evidence overlap was carried out using AMSTAR 2, PRISMA 2020, ROBIS, GRADE, and GROOVE frameworks. Results: Seven SRs met inclusion criteria. Curcumins demonstrated potential efficacy and safety advantages over control treatments in KOA management. However, these reviews were of extremely low methodological quality, with poor reporting and significant information gaps. High risk of bias was noted in four SRs. Among 48 outcomes assessed, evidence quality was mostly low, with 5 medium-quality, 6 low-quality, and 37 extremely low-quality evidences. Significant literature overlap was evident. Conclusion: The current SRs on curcumins for KOA are of low quality. Future research should adhere to rigorous quality assessment standards, increase sample sizes to minimize overlap, and thoroughly evaluate evidence quality to enhance the reliability and rigor of evidence supporting clinical practice. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42025641801, identifier CRD42025641801.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.