Evidence map›Paper›PMID 41560712›Full record

ArticleO&G open2026

Medication for Opioid Use Disorder and Perioperative Outcomes for Benign Hysterectomy.

Yongmei Huang, Alicia H Li, June Y Hou, Pia M Mauro, Xiao Xu, Guohua Li, Adam Bisaga, Dawn L Hershman, Silvia S Martins, Jason D Wright

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in O&G open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongmei HuangDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Alicia H LiDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
June Y HouDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Pia M MauroDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Xiao XuDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Guohua LiDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Adam BisagaDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Dawn L HershmanDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Silvia S MartinsDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.
Jason D WrightDepartment of Obstetrics and Gynecology, Department of Anesthesiology, and Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York; Center for Pharmacoepidemiology and Treatment Science, Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey; and New York State Psychiatric Institute, New York, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between medication for opioid use disorder (MOUD) and surgical complications and health care utilization among patients with opioid use disorder (OUD) undergoing hysterectomy.

methodsUsing MarketScan Research Databases (2016-2021), we identified patients with OUD who underwent hysterectomy for benign indications. Use of MOUD (methadone or buprenorphine) was assessed within 1 year preoperatively, distinguishing among prior MOUD use (365 to 31 days preoperatively), current MOUD use (30 to 1 days preoperatively), and nonuse of MOUD. The primary outcomes included perioperative surgical complications. The secondary outcome included perioperative and postoperative opioid prescription, 30-day readmissions, and emergency department (ED) visits within 30 and 90 days. Propensity scores inverse probability of treatment weighting was used to evaluate the association between current MOUD and outcomes.

resultsOf 1,715 patients with preoperative OUD who underwent hysterectomy, 491 (28.6%, 95% CI, 26.5-30.8%) reported current MOUD use. Current MOUD use was associated with fewer perioperative complications than nonuse of MOUD (27.7% vs 33.9%, adjusted risk ratio 0.86, 95% CI, 0.76-0.97), including surgical site (12.8% vs 16.9%) and medical (17.5% vs 22.8%) complications. Current MOUD use was also associated with fewer ED visits within 30 days (19.1% vs 27.7%) and 90 days (32.6% vs 42.8%). Buprenorphine and methadone had similar outcomes. Patients on MOUD for more than 90 days had lower risks of complications and health care utilization than those on MOUD for 90 days or less.

conclusionAmong patients with OUD undergoing hysterectomy, MOUD use was associated with reduced perioperative complications and health care utilization. Findings support methadone and buprenorphine use to improve hysterectomy surgical outcomes, particularly with more than 90 days of MOUD.

Identifiers

PMID41560712
PMCPMC12815545

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