Evidence map›Paper›PMID 41560629›Full record

ReviewJournal of sleep research2026

Atlas and Updated Rules for the Scoring of Cyclic Alternating Pattern (CAP) in Human Sleep. A Consensus Report by a Taskforce of the European Sleep Research Society.

Liborio Parrino, Heidur Gretarsdottir, Robert Thomas, Ivana Rosenzweig, Oliviero Bruni, Gulcin Benbir Senel, Fábio Mendonça, Antonio G Ravelo García, Erna Sif Arnardóttir, Raffaele Ferri

Abstract readConsensus StatementReview
In one paragraph

Review in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liborio Parrino"Mario Giovanni Terzano" Sleep Disorders Center, University of Parma, Parma, Italy.ORCID https://orcid.org/0000-0002-4035-6234
Heidur GretarsdottirReykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
Robert ThomasDivision of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Ivana RosenzweigSleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Oliviero BruniDepartment of Human Neuroscience, Sapienza University, Rome, Italy.ORCID https://orcid.org/0000-0003-2207-1398
Gulcin Benbir SenelDivision of Clinical Neurophysiology, Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Fábio MendonçaUniversity of Madeira, Funchal, Portugal.
Antonio G Ravelo GarcíaInteractive Technologies Institute (ITI/ARDITI/LARSyS), Funchal, Portugal.
Erna Sif ArnardóttirReykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
Raffaele FerriSleep Research Centre, Oasi Research Institute-IRCCS, Troina, Italy.

Funding

AEI-ACIISI ProID2024010015European Union's Horizon 2020 Research and Innovation Programme 965417Fundação para a Ciência e a TecnologiaItalian Ministry of Health 2793745ITI/LARSyS
6 · The paper itself

Abstract

The cyclic alternating pattern is a hallmark of the dynamic organisation of non-rapid eye movement sleep, reflecting the brain's oscillatory regulation of arousal and sleep stability. Since the original publication of the rules for scoring the cyclic alternating pattern in 2001, major advances in sleep neurophysiology, signal analysis and international sleep staging standards have necessitated a comprehensive revision. This consensus report by a Taskforce of the European Sleep Research Society presents the updated 2025 Atlas and Rules for the scoring of the cyclic alternating pattern in human sleep. The new guidelines preserve the foundational framework of the cyclic alternating pattern while introducing several critical innovations: (i) expanded definitions and a broader catalogue of Phase A electroencephalographic patterns; (ii) refined onset and offset criteria based on amplitude and frequency shifts, with strict inter-lead concordance requirements; (iii) standardised metrics for the quantification and reporting of the cyclic alternating pattern; (iv) formal guidance for scoring the cyclic alternating pattern in paediatric populations and optional scoring in rapid eye movement sleep; and (v) a technical framework for computerised detection and analysis. These updates align scoring with contemporary sleep staging standards, enhancing precision, reproducibility and applicability across research and clinical contexts.

Indexed as

ElectroencephalographyPolysomnographySleepSleep StagesArousalEuropeHumansarousal regulationelectroencephalographyneurophysiologysleep instabilitysleep microstructuresleep staging

Identifiers

PMID41560629
PMCPMC13357963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.