Evidence map›Paper›PMID 41560554›Full record

ArticleVirulence2026

Exogenous indole promotes florfenicol tolerance in

Yu Zheng, Luhua Fu, Zhuoying Cao, Ting Zhang, Jiao Fei, Ming Jiang, Yuying Zhou, Zhi Shi, Yubin Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu ZhengDepartment of Immunology and Microbiology & Institute of Medical Microbiology, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Luhua FuDepartment of General Practice, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Zhuoying CaoDepartment of Immunology and Microbiology & Institute of Medical Microbiology, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Ting ZhangDepartment of Immunology and Microbiology & Institute of Medical Microbiology, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Jiao FeiState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Ming JiangCollege of Life Sciences, Hunan Normal University, Changsha, China.
Yuying ZhouDepartment of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Zhi ShiDepartment of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.
Yubin SuDepartment of Immunology and Microbiology & Institute of Medical Microbiology, MOE Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China.ORCID 0000-0001-5300-7765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial metabolism is important for antibiotic resistance and tolerance. However, the impact of indole on bacterial metabolism and antibiotic efficacy has not been fully elucidated. In this study, we investigated the effect and specific mechanism of exogenous indole on the antibiotic susceptibility of

Indexed as

Anti-Bacterial AgentsEdwardsiella tardaIndolesThiamphenicolAnimalsCitric Acid CycleDrug Resistance, BacterialEnterobacteriaceae InfectionsFish DiseasesMetabolomeOxidative StressReactive Oxygen SpeciesAnti-Bacterial AgentsflorfenicolindoleIndolesReactive Oxygen SpeciesThiamphenicolantibiotic toleranceEdwardsiella tardaindolemetabolic reprogrammingreactive oxygen species

Identifiers

PMID41560554
PMCPMC12834173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.