ArticleThe Journal of organic chemistry2026
Ring-Opening of Aziridines Using Tethered Hemiketals.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Ring-Opening of Aziridines Using Tethered Hemiketals.The Journal of organic chemistry · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
We present the first examples of aziridine ring-opening reactions by pendant hemiketal tethers. The reactions proceed smoothly at room temperature with catalytic quantities of the Lewis acid triphenylcarbenium tetrafluoroborate. The hemiketal tether is derived from the reaction solvent, acetone, in most cases. Other ketone solvents, including cyclopentanone and cyclobutanone, are also compatible. We hypothesize that the Lewis acid catalyzes the addition of the solvent to the alcohol of the aziridine substrate, forming a hemiketal tether, which then attacks the aziridine in an S
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Registered trials
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