Evidence map›Paper›PMID 41560473›Full record

ArticleProteins2026

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases.

A X Quintana-Armas, E Flores-Hernández, C Cardona-Félix, E Rudiño-Piñera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A X Quintana-ArmasLaboratorio de Bioquímica Estructural, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
E Flores-HernándezLaboratorio de Bioquímica Estructural, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
C Cardona-FélixSECIHTI - Centro de Investigaciones Biológicas del Noroeste (CIBNOR-Unidad La Paz), La Paz, Baja California Sur, México.
E Rudiño-PiñeraLaboratorio de Bioquímica Estructural, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.ORCID https://orcid.org/0000-0001-8170-6379

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 2019-000037-02NACF-23048Consjeo Nacional de Humanidades, Ciencias y Tecnologías 2019-000037-02NACF-23048Instituto de Biotecnología, UNAMPrograma de Apoyos a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) IN226523Sistema Nacional de Investigadoras e Investigadores (SNII), México
6 · The paper itself

Abstract

We present the first x-ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis. Our crystallographic models of Thermococcus gammatolerans DNA ligase (LigTgam), coupled with bioinformatic analysis of at least 28 crystallographic structures from ATP- and NAD

Indexed as

Archaeal ProteinsDNA LigasesAdenosine MonophosphateAdenosine TriphosphateAmino Acid SequenceBinding SitesCatalytic DomainCrystallography, X-RayDNADNA Ligase ATPHydrolysisModels, MolecularProtein BindingRecombinant ProteinsAdenosine MonophosphateAdenosine TriphosphateArchaeal ProteinsDNADNA Ligase ATPDNA LigasesRecombinant ProteinsB‐factorsDNA‐binding proteinsDNA ligasesoligonucleotide binding domainprotein mobilityx‐ray crystallography

Identifiers

PMID41560473
PMCPMC13136779

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.