Evidence map›Paper›PMID 41560336›Full record

Trial reportClinical and translational science2026

Open-Label Study Assessing Relative and Absolute Bioavailability of Oral Camizestrant Formulations and Food Effects in Healthy Postmenopausal Women.

Andy Sykes, Helena Engman, Nigel Taylor, Tim Brier, Rhiannon Maudsley, Bistra Kirova, Alastair M Mathewson, Ryan A Bragg, Malin Gränfors, Eric T Gangl and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andy SykesClinical Pharmacology and Quantitative Pharmacology, AstraZeneca, Cambridge, UK.ORCID 0000-0003-2257-4841
Helena EngmanGlobal Product Development, Product Development and Technology, Global Operations, AstraZeneca, Gothenburg, Sweden.ORCID 0009-0009-4145-2816
Nigel TaylorGlobal Pharmaceutical Project, AstraZeneca, Macclesfield, UK.ORCID 0000-0002-3655-5249
Tim BrierResearch and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID 0009-0006-5218-1730
Rhiannon MaudsleyOncology Biometrics, Research and Development, AstraZeneca, Cambridge, UK.ORCID 0009-0007-4877-6990
Bistra KirovaOncology Patient Safety, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID 0009-0002-7493-7480
Alastair M MathewsonResearch and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID 0009-0000-2435-9235
Ryan A BraggEarly Chemical Development, Pharmaceutical Sciences, Research and Development, AstraZeneca, Cambridge, UK.ORCID 0000-0002-7545-8628
Malin GränforsEarly Product Development and Manufacturing, Pharmaceutical Sciences, Research and Development, AstraZeneca, Gothenburg, Sweden.
Eric T GanglResearch and Early Development, Oncology Research and Development, AstraZeneca, Boston, Massachusetts, USA.ORCID 0000-0001-5243-2524
Teresa KlinowskaLate Development, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0003-1997-7340
Yan LiResearch and Early Development, Oncology Research and Development, AstraZeneca, Boston, Massachusetts, USA.ORCID 0000-0003-3673-181X
Somasekhar R MenakuruQuotient Sciences, Nottingham, UK.ORCID 0009-0005-7028-7697
Chris RoeQuotient Sciences, Nottingham, UK.ORCID 0000-0001-6988-5132
John McDermottQuotient Sciences, Nottingham, UK.ORCID 0009-0003-0135-7757
Justin P O LindemannResearch and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0003-1531-9754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Camizestrant is the next-generation oral selective estrogen receptor degrader and complete estrogen receptor antagonist in Phase 3 development for hormone receptor-positive breast cancer. To investigate the impact of manufacturing changes during pivotal Phase 3 studies, this open-label, randomized crossover study of 32 postmenopausal healthy volunteers determined the relative bioavailability of a tablet used in early clinical studies (Phase 1 tablet), a tablet designed for late-phase development (prototype Phase 3 tablet), and an oral solution. Absolute oral bioavailability in the fasted state (using a [

Indexed as

Food-Drug InteractionsPostmenopauseAdministration, OralAgedArea Under CurveAzetidinesBiological AvailabilityCross-Over StudiesFastingFemaleHealthy VolunteersHumansIsoquinolinesMiddle AgedTabletsAZD9833AzetidinesIsoquinolinesTabletsbioavailabilityclinical pharmacologyfood effecthealthy volunteerspharmacokineticsselective estrogen receptor degrader

Identifiers

PMID41560336
PMCPMC12820339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.