Evidence map›Paper›PMID 41560230›Full record

ArticlePhysical review. E2025

Minimax entropy: The statistical physics of optimal models.

David P Carcamo, Nicholas J Weaver, Purushottam D Dixit, Christopher W Lynn

Abstract read
In one paragraph

Article in Physical review. E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Quantifying the compressibility of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David P CarcamoYale University, Department of Physics, New Haven, Connecticut, USA.
Nicholas J WeaverYale University, Department of Physics, New Haven, Connecticut, USA.
Purushottam D DixitYale University, Department of Biomedical Engineering, New Haven, Connecticut, USA.
Christopher W LynnYale University, Department of Physics, New Haven, Connecticut, USA.

Funding

MANET: Maximum Entropy Neural Networks for Mechanistic Modeling of Single Cell BehaviorR35GM142547 · NIGMS · YALE UNIVERSITY · PI DIXIT, PURUSHOTTAM · 2021 to 2025
$1.9M
Minimax entropy: Optimal statistical models for neural activity and chromatin structureR35GM160188 · NIGMS · YALE UNIVERSITY · PI Christopher Lynn · 2025 to 2026
$923k
NIGMS NIH HHS R35 GM142547NIGMS NIH HHS R35 GM160188
6 · The paper itself

Abstract

When constructing models of the world, we aim for optimal compressions: models that include as few details as possible while remaining as accurate as possible. But which details-or features measured in data-should we choose to include in a model? Here, using the minimum description length principle, we show that the optimal features are the ones that produce the maximum entropy model with minimum entropy, thus yielding a minimax entropy principle. We review applications, which range from machine learning to optimal models of biological networks. Naive implementations, however, are limited to systems with small numbers of states and features. We therefore require new theoretical insights and computational techniques to construct optimal compressions of high-dimensional datasets arising in large-scale experiments.

Identifiers

PMID41560230
PMCPMC13220842

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.