Observational studyMedicine2026
Study on the effects of zirconia restorations in oral prosthodontics on inflammatory factor levels and masticatory function.
Observational study in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to compare the effects of zirconia all-ceramic crowns and metal-ceramic crowns on inflammation and chewing function in patients receiving full-crown restorations and to explore whether improvements in gingival health mediate these effects - an aspect rarely addressed in previous studies. A total of 196 patients treated from January 2023 to January 2024 were included. After propensity score matching, 79 patients in each group had similar baseline characteristics. Serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels were measured before treatment and at 6 weeks and 3 months after restoration. Masticatory efficiency, visual analogue scale (VAS) scores, gingival condition, and clinical success were also evaluated. Both groups showed significant decreases in IL-6, TNF-α, and CRP after restoration, with greater reductions in the zirconia group (3-month IL-6: 7.2 ± 2.0 vs 9.8 ± 2.5 pg/mL; TNF-α: 11.5 ± 2.7 vs 14.3 ± 3.0 pg/mL; CRP: 3.5 ± 1.0 vs 4.8 ± 1.3 mg/L; all P < .001). The zirconia group also showed higher chewing efficiency (78.6 ± 9.2% vs 70.2 ± 8.9%), higher VAS scores (7.8 ± 1.0 vs 6.9 ± 1.1), and fewer gingival symptoms (7.6% vs 17.7%, all P < .05). Mediation analysis revealed that part of the CRP reduction was mediated by improved gingival health, providing novel mechanistic insight. This study not only confirms the superior clinical and anti-inflammatory effects of zirconia restorations over metal-ceramic crowns but also identifies gingival health as a potential mediator linking restorative material and systemic inflammation. These findings provide new evidence for the biological advantages of zirconia in prosthodontic practice.
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