Evidence map›Paper›PMID 41559892›Full record

ArticleOrganic letters2026

Synthesis of the Proposed Structure of Celacarfurine and Analogues Using Sequential Cascade Ring Expansion Reactions.

Jerry K F Tam, Lachlan J N Waddell, Kleopas Y Palate, Adrian C Whitwood, Alexandra Longcake, Michael R Probert, Gideon Grogan, Benjamin R Lichman, William P Unsworth

Abstract read
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In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jerry K F TamUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.
Lachlan J N WaddellUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.
Kleopas Y PalateUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.
Adrian C WhitwoodUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.ORCID 0000-0002-5132-5468
Alexandra LongcakeSchool of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, U.K.ORCID 0000-0003-2881-3938
Michael R ProbertSchool of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, U.K.
Gideon GroganUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.ORCID 0000-0003-1383-7056
Benjamin R LichmanUniversity of York, Department of Biology, Heslington, York YO10 5DD, U.K.ORCID 0000-0002-0033-1120
William P UnsworthUniversity of York, Department of Chemistry, Heslington, York YO10 5DD, U.K.ORCID 0000-0002-9169-5156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first synthesis of the proposed structure of spermidine derived macrocyclic alkaloid celacarfurine is described. A versatile synthetic strategy has been developed based on sequential cascade ring expansion reactions, with high dilution conditions not needed for any of the steps. The same general strategy was also used to generate a series of macrocyclic analogues. The physical properties and spectroscopic data obtained for our synthetic product do not match those reported for the isolated alkaloid.

Identifiers

PMID41559892
PMCPMC12865764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.