Evidence map›Paper›PMID 41559884›Full record

ArticleMolecular microbiology2026

Elongation Factor Tu Acts as a Chaperone to Activate an Antibacterial RNase Toxin.

Dinh Quan Nhan, Karolina Michalska, Fernando Garza-Sánchez, Nicholas L Bartelli, Julia L E Willett, Lucy Stols, William H Eschenfeldt, Celia W Goulding, Andrzej Joachimiak, Christopher S Hayes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dinh Quan NhanDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Karolina MichalskaCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
Fernando Garza-SánchezDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Nicholas L BartelliDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Julia L E WillettDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.
Lucy StolsCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
William H EschenfeldtCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
Celia W GouldingDepartment of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, California, USA.
Andrzej JoachimiakCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA.
Christopher S HayesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA.ORCID 0000-0002-2216-6445

Funding

Midwest Center for Structural GenomicsU54GM094585 · NIGMS · UNIVERSITY OF CHICAGO · PI EDWARDS, ALED M · 2010 to 2014
$33.7M
TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
Molecular Mechanisms of anti-bacterial contact-dependent growth inhibition (CDI)R01GM117930 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2016 to 2023
$3.0M
The Midwest Center for Structural Genomics - Community ResourceR24GM115586 · NIGMS · UNIVERSITY OF CHICAGO · PI JOACHIMIAK, ANDRZEJ · 2015 to 2017
$2.8M
Structure-function analysis of polymorphic CDI toxin-immunity protein complexes aU01GM102318 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOULDING, CELIA · 2012 to 2016
$1.7M
Function of novel antibacterial toxinsR01GM144437 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GOULDING, CELIA, HAYES, CHRISTOPHER S. · 2022 to 2025
$1.3M
NIGMS NIH HHS R01 GM117930NIGMS NIH HHS R01 GM144437NIGMS NIH HHS R24 GM115586NIGMS NIH HHS U01 GM102318NIGMS NIH HHS U54 GM094585NIH HHS 75N93022C00035NIH HHS GM094585NIH HHS GM102318NIH HHS GM115586NIH HHS GM144437U.S. Department of Energy DE-AC02-06CH11357
6 · The paper itself

Abstract

Many Gram-negative bacterial species use contact-dependent growth inhibition (CDI) systems to deliver toxic proteins into neighboring competitors. CDI

Indexed as

Bacterial ToxinsEscherichia coliEscherichia coli ProteinsMolecular ChaperonesPeptide Elongation Factor TuRibonucleasesCrystallography, X-RayGTP PhosphohydrolasesMembrane ProteinsModels, MolecularProtein BindingBacterial ToxinsCdiA protein, E coliEscherichia coli ProteinsGTP PhosphohydrolasesMembrane ProteinsMolecular ChaperonesPeptide Elongation Factor TuRibonucleases

Identifiers

PMID41559884
PMCPMC12991825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.