Evidence map›Paper›PMID 41559805›Full record

ArticleBiology direct2026

Polarity protein Par3 deficiency promotes metastasis of bladder cancer via interaction of Ppp1r12c.

Jinming Cai, Can Jiao, Yingying Xu, Fang Zhang, Li Zhang, She Chen, Bing Shen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jinming Cai *Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Can Jiao *NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200030, China.
Yingying XuNHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200030, China.
Fang ZhangDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Li ZhangNHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200030, China.
She ChenNHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200030, China. shechen@fudan.edu.cn.
Bing ShenDepartment of Urology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, 200072, China. urodrshenbing@shsmu.edu.cn.

Funding

National Natural Science Foundation of China 82472669National Natural Science Foundation of China (NSFC) 82572658Natural Science Foundation of Shanghai #23ZR1412600
6 · The paper itself

Abstract

backgroundBladder cancer (BC) remains the leading global mortality and poor prognosis in genitourinary malignancies, especially in patients with metastasis.

resultsIn this study, we demonstrate that loss of polarity protein partitioning defective 3 (Par3, encoded by PARD3) is correlated with stronger metastatic capability and a poorer prognosis in BC. Par3 deletion in high grade BC cells accelerates their invasion and metastasis in vitro and in vivo. Mechanistically, Par3 could directly interact with protein phosphatase 1 regulatory subunit 12 C (Ppp1r12c). Either Par3 or Ppp1r12c over-expression rescues the invasion and metastasis caused by Par3 deficiency in vitro. Moreover, the actin filament-related processions are enriched in the downstream biological function, resulting from the activation of ERK 1/2 and p38 signaling pathways, indicated by proteomics analysis from BC cells and tissue, as well as data mining results from BC public database.

conclusionTogether, our study reveals that Par3 deficiency promotes BC metastasis. Par3 directly interacts with Ppp1r12c (390-782aa), activating the Par3/Ppp1r12c/ERK/p38 axis. Par3 could act as a prognostic biomarker and potential therapeutic target for BC.

Indexed as

Adaptor Proteins, Signal TransducingCell Cycle ProteinsMembrane ProteinsProtein Phosphatase 1Urinary Bladder NeoplasmsAnimalsCell Line, TumorFemaleHumansMiceNeoplasm MetastasisAdaptor Proteins, Signal TransducingCell Cycle ProteinsMembrane ProteinsPARD3 protein, humanProtein Phosphatase 1Bladder cancerMAPKMetastasisPar3Ppp1r12c

Identifiers

PMID41559805
PMCPMC12903734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.