Evidence map›Paper›PMID 41559796›Full record

ArticleActa neuropathologica communications2026

Mislocalization of FTD3-associated mutant CHMP2B to the nucleus of human neurons due to loss of a nuclear export signal.

Yong-Woo Jun, Evan P Hass, Soojin Lee, Thomas G Fazzio, Fen-Biao Gao

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yong-Woo JunFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Evan P HassDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Soojin LeeFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Thomas G FazzioDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Fen-Biao GaoFrontotemporal Dementia Research Center, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. fen-biao.gao@umassmed.edu.

Funding

Roles of Chromatin Regulation in Embryonic Stem Cell Self-RenewalR01HD072122 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Thomas G Fazzio · 2012 to 2026
$5.9M
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1M
NICHD NIH HHS R01 HD072122NINDS NIH HHS R01 NS101986NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986
6 · The paper itself

Abstract

Frontotemporal dementia linked to chromosome 3 (FTD3) is caused by a splice site point mutation in CHMP2B, resulting in the production of mutant proteins CHMP2B

Indexed as

Cell NucleusFrontotemporal DementiaNerve Tissue ProteinsNeuronsNuclear Export SignalsActive Transport, Cell NucleusCells, CulturedCerebral CortexCytoplasmEndosomal Sorting Complexes Required for TransportExportin 1 ProteinHumansInduced Pluripotent Stem CellsKaryopherinsMutationReceptors, Cytoplasmic and NuclearCHMP2B protein, humanEndosomal Sorting Complexes Required for TransportExportin 1 ProteinKaryopherinsNerve Tissue ProteinsNuclear Export SignalsReceptors, Cytoplasmic and NuclearCHMP2BCRM1CytoplasmESCRTExportFTDiPSCNeuronsNuclear export signalNucleus

Identifiers

PMID41559796
PMCPMC12918131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.