Evidence map›Paper›PMID 41559767›Full record

ArticleBMC psychology2026

The white matter of Aha! moments.

Carola Salvi, Simone A Luchini, Franco Pestilli, Sandra Hanekamp, Todd Parrish, Mark Beeman, Jordan Grafman

Abstract read
In one paragraph

Article in BMC psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Creativity: a (white) matter of connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Carola SalviDepartment of Psychology, Universita` Cattolica del Sacro Cuore, Milan, EU, Italy. carola.salvi@gmail.com.
Simone A LuchiniDepartment of Psychology, Pennsylvania State University, University Park, PA, USA.
Franco PestilliThe University of Texas at Austin, Austin, TX, USA.
Sandra HanekampThe University of Texas at Austin, Austin, TX, USA.
Todd ParrishDepartment of Radiology, Northwestern University, Chicago, IL, USA.
Mark BeemanDepartment of Psychology, Northwestern University, Chicago, IL, USA.
Jordan GrafmanDepartment of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Funding

TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
NINDS NIH HHS T32 NS047987United States Air Force Research Laboratory FA8650-15-2-5518
6 · The paper itself

Abstract

Insights, or "Aha!" moments, are a crucial aspect of idea generation in creative cognition. While functional neuroimaging studies have identified brain regions involved in these insights, their white matter substrate remains unexplored. This study employed diffusion tensor imaging (DTI) to investigate how white matter microstructure—measured by fractional anisotropy (FA) and mean diffusivity (MD)—relates to individuals’ tendency to solve Compound Remote Associates problems through insight versus step-by-step analytical reasoning. After controlling for age and gender, left-hemisphere omnibus tests (Stouffer’s Z and FDR) showed significant FA associations for left dorsal tracts composites (i.e., Arcuate Fasciculus, Posterior Arcuate Fasciculus, and Superior Longitudinal Fasciculus III), while MD tracts composites trended but were not FDR-significant (p= 0.032 q= 0.081). Findings point to a left-lateralized dorsal substrate of insight. These findings suggest that insight may benefit from more diffuse connectivity patterns, allowing for broader semantic activation and cognitive flexibility. Our study provides novel evidence for distinct structural connectivity patterns associated with different idea-generation approaches, contributing to a more comprehensive understanding of the neural architecture supporting creative cognition.

Indexed as

BrainCreativityProblem SolvingWhite MatterAdultAnisotropyDiffusion Tensor ImagingFemaleHumansMaleYoung AdultCreativityDiffusion tensor imagingInsightProblem solvingWhite matter microstructure

Identifiers

PMID41559767
PMCPMC12866244

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.