Evidence map›Paper›PMID 41559718›Full record

ArticleBMC chemistry2026

Adamantane-thiazole hybrids and related derivatives: synthesis, crystal structures, in vitro antibacterial, antifungal, and anti-proliferative activities.

Heidi S Abd El-Monaem, Mahmoud B El-Ashmawy, Naglaa I Abdel-Aziz, Olivier Blacque, E Habib, Subbiah Thamotharan, Ali A El-Emam

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Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heidi S Abd El-MonaemDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Mahmoud B El-AshmawyDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Naglaa I Abdel-AzizDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Olivier BlacqueDepartment of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
E HabibDepartment of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Subbiah ThamotharanBiomolecular Crystallography Laboratory and DBT-Bioinformatics Center, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613 401, India. thamu@scbt.sastra.edu.
Ali A El-EmamDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. elemam@mans.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Series of 2-(adamantan-2-ylidene)-N-substituted hydrazine-1-carbothioamide derivatives 5a-d and (E)-2-[(adamantan-2-ylidene)hydrazono]-3,4-diaryl-2,3-dihydrothiazole derivatives 7a-l were prepared and their structures were confirmed. In vitro antimicrobial evaluation of compounds 5a-d and 7a-l against different pathogenic bacterial and fungal strains revealed that compounds 5a, 5b, 5c, 7a, 7f, 7i and 7k displayed notable effectiveness against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and the Gram-negative Escherichia coli, and all compounds lacked antifungal activity. In addition, compounds 5a, 5b, 5c, 7f and 7 L displayed marked anti-proliferative activity particularly against HepG-2 and MCF-7 cancer cell lines (IC

Indexed as

AdamantaneAntimicrobial activityAnti-proliferative activityMolecular dockingSingle crystal XRDThiazole

Identifiers

PMID41559718
PMCPMC12905878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.