Evidence map›Paper›PMID 41559671›Full record

ArticleHarm reduction journal2026

Unintentional benzodiazepine use and frequency of drug checking service utilization: a cross-sectional study.

Lauren Airth, Trevor Goodyear, Brandon D L Marshall, Cameron Grant, Mark Lysyshyn, Susan G Sherman, Evan Wood, Lianping Ti

Erratum issuedAbstract read
In one paragraph

Article in Harm reduction journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lauren AirthBritish Columbia Centre On Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Trevor GoodyearBritish Columbia Centre On Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, 121 S Main St, Providence, Rhode Island, 02903, USA.
Cameron GrantBritish Columbia Centre On Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Mark LysyshynVancouver Coastal Health, 600-601 West Broadway, Vancouver, BC, V5Z 4C2, Canada.
Susan G ShermanDepartment of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway Street, Baltimore, MD, 21205, USA.
Evan WoodBritish Columbia Centre On Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.
Lianping TiBritish Columbia Centre On Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada. bccsu-lt@bccsu.ubc.ca.

Funding

Evaluation of Drug Checking as a Novel Intervention to Address the Opioid Overdose Crisis Attributable to Fentanyl and its AnaloguesR01DA052381 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI TI, LIANPING · 2021 to 2023
$1.4M
NIDA NIH HHS R01 DA052381NIH HHS R01DA052381
6 · The paper itself

Abstract

backgroundThere are increasing accounts of benzodiazepine adulteration and contamination in the unregulated drug supply in Canada and internationally. In some Canadian settings, drug checking services (DCS) are available for people to identify the constituents of their drugs. This study examines the relationship between suspected, unintentional benzodiazepine consumption and DCS utilization frequency, and whether gender modifies this relationship. We hypothesized that suspected unintentional benzodiazepine consumption would predict frequent DCS utilization, particularly for women, who may be at heightened risk for pertinent harms related to benzodiazepine use.

methodsData were drawn from a cross-sectional study (2021-2023) evaluating DCS that used spectroscopy and immunoassay strips in British Columbia, Canada. Multivariable ordinal logistic regression was used to examine the relationship between suspected unintentional benzodiazepine consumption and DCS utilization frequency, categorized as: once, > once and < once/month, once/month, > once/month and < three times/month, weekly, and > weekly. Potential confounders included age, population centre size, and frequent unregulated opioid use (≥ weekly). In planned exploratory analyses, gender was included as a possible effect modifier.

resultsOf 220 participants, 73 (33.2%) were women and 143 (65.0%) believed they had unintentionally consumed benzodiazepines in the previous six months. Bivariable ordinal regression showed a significant relationship between suspected unintentional benzodiazepine consumption and DCS utilization frequency (odds ratio [OR]: 2.11; 95% confidence interval [CI]: 1.22-3.69). However, after adjusting for confounders, particularly frequent unregulated opioid use, this association was no longer statistically significant (adjusted OR: 1.49; 95%CI: 0.75-2.99). We also failed to find that gender modified the relationship between suspected unintentional benzodiazepine consumption and DCS utilization.

conclusionsFindings suggest that frequent unregulated opioid use may best explain the frequency of DCS utilization. Although gender did not significantly modify the association between suspected unintentional benzodiazepine consumption and frequency of DCS utilization, continued research should explore the role and context of gender in this relationship.

Indexed as

BenzodiazepinesSubstance-Related DisordersAdultBritish ColumbiaCross-Sectional StudiesFemaleHumansMaleMiddle AgedSex FactorsYoung AdultBenzodiazepinesBenzodiazepinesDrug checkingGenderHarm reductionPublic healthUnregulated drugs

Identifiers

PMID41559671
PMCPMC12903681

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.