ArticleBMC public health2026
Age modifies the relationship between ultra-processed food intake and hyperuricemia: findings from NHANES 1999-2018.
Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperuricemia is a growing public health concern linked to gout, cardiovascular diseases, and metabolic syndrome. Ultra-processed foods (UPFs), characterized by industrial formulation with additives and minimal whole food content, have been hypothesized to be linked to uric acid overproduction through high levels of sugars, unhealthy fats, and purine precursors. This study aimed to investigate the association between UPF consumption and hyperuricemia across different age groups, hypothesizing that higher UPF intake is associated with higher odds of hyperuricemia, particularly in individuals under 60 years.
methodsData from 43,713 adults aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 were analyzed. Logistic regression models adjusted for sociodemographic, clinical, and lifestyle factors were used to assess the association between UPF ratio and hyperuricemia. Generalized additive models and stratified analyses were employed to evaluate non-linear relationships and potential interactions.
resultsIn fully adjusted models, each unit increase in UPF ratio was associated with 31% higher odds of hyperuricemia in the total population (OR 1.31, 95% CI 1.15–1.48, P < 0.001). This association was strongest among middle-aged adults (45–59 years) (OR 1.49, 95% CI 1.15–1.92, P < 0.01), followed by young adults (< 45 years) (OR 1.35, 95% CI 1.10–1.66, P < 0.01), while no significant association was observed among older adults (≥ 60 years). Significant interactions modifying the UPF-hyperuricemia association were observed for race/ethnicity, drinking status, and diabetes in young adults, and for gender, race/ethnicity, and drinking status in older adults.
conclusionsUPF consumption is significantly associated with higher odds of hyperuricemia in adults under 60 years, with the strongest association observed in middle-aged adults. Age substantially modifies this relationship, with no significant association in adults aged ≥ 60 years. These findings suggest that age-specific dietary recommendations targeting UPF reduction may be relevant for hyperuricemia management, particularly in younger and middle-aged populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.