ArticleJournal of natural medicines2026
Effect of Shin'iseihaito (Xinyiqingfeitang) on MUC5AC expression in cultured pulmonary epithelial cells and the role of its component gypsum.
Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Shin’iseihaito (xinyiqingfeitang in Chinese, SSHT) is a formula of traditional Japanese Kampo medicine and Chinese medicine composing nine crude drugs, Gypsum (GF), Magnolia Flower (MS), Ophiopogon Tuber (OJ), Cimicifuga Rhizome (AS), Loquat Leaf (EJ), Scutellaria Root (SB), Gardenia Fruit, Anemarrhena Rhizome, and Lilium Bulb, and its indications are chronic sinusitis and nasal obstruction. The surface of the paranasal sinuses epithelium is covered with a mucous layer composed of mucin (MUC), and MUC5AC is the main component in airway mucus. Once inflammation is induced by bacteria, the overexpression of MUC5AC is induced to cause the symptoms of sinusitis. The suppressive effect on overexpressed MUC5AC is related to relieving nasal obstruction. In this study, we evaluated the suppressive effect of SSHT extract on phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC production from human pulmonary mucoepidermoid carcinoma NCI-H292 cells. SSHT extract significantly suppressed PMA-induced MUC5AC production and its mRNA expression. Among crude drugs composing SSHT, the extracts of GF, MS, OJ, AS, EJ, and SB showed significant effects on PMA-induced MUC5AC production evaluated by ELISA. The extracts of AS, SB and GF inhibited its mRNA expression by RT-qPCR. GF extract and CaSO4, the main ingredient of GF, suppressed both PMA-induced MUC5AC production and mRNA expression in concentration-dependent manners, and CaSO4 almost contributed to the effect of GF extract. Among ions, Ca2+ exhibited the significant inhibitory effect on PMA-induced MUC5AC mRNA expression, and Ca2+ within the range of concentrations that can be varied in human blood showed significant effects. In traditional Chinese medicine, GF belongs to heat-clearing drugs and is expected to have anti-inflammatory effects, but it does not contain any organic compounds that may be effective. However, this study revealed that the Ca2+ contained in GF may have a certain level of anti-inflammatory effects.
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