Evidence map›Paper›PMID 41559489›Full record

Observational studyEuropean journal of pediatrics2026

Hemodynamic changes in neonatal hypoxic-ischemic encephalopathy requiring therapeutic hypothermia.

Shuhan Yu, Tiantian Xiao, Biao Li, Qi Zhang, Jingyi Zhang, Juetao Fu, Xueli Lu, Yongzhong Zhou, Mingsheng Zheng, Xin Ding and 4 more

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Timing of echocardiography in the hemodynamic assessment of neonatal hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Shuhan YuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Tiantian XiaoDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Biao LiDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Qi ZhangSchool of Mathematical Sciences, the Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China.
Jingyi ZhangDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Juetao FuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Xueli LuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yongzhong ZhouSchool of Mathematics, Southwestern University of Finance and Economics, Chengdu, 611130, China.
Mingsheng ZhengDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Xin DingSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, Suzhou, 215025, China.
Sheng YangDepartment of Ultrasonography, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Qing GaoSchool of Mathematical Sciences, the Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, 611731, P.R. China. gaoqing@uestc.edu.cn.
Yiyong FuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China. 397657412@qq.com.
Rong JuDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective observational study investigated the hemodynamic changes in cardiac function and cerebral blood flow velocity (CBFV) in neonates with hypoxic-ischemic encephalopathy (HIE) requiring therapeutic hypothermia (TH). Data were collected at five timepoints, viz., pre-TH (T0), 0-24 h of TH (T1), 24-48 h of TH (T2), 48-72 h of TH (T3), and within 24 h postrewarming (T4). Healthy neonates served as the control group (n = 20). A total of 43 neonates with HIE requiring TH were enrolled. Left ventricular output was significantly lower than that in the control group at T1 and T2 and increased from T1 to T4 (92.8 ± 29.5 ml/kg/min vs. 103 ± 29.7 ml/kg/min vs. 109.5 ± 28 ml/kg/min vs. 144.5 ± 34.4 ml/kg/min (T4 vs. T1, T2, or T3: p < 0.05). Systolic mitral annular velocity and systolic tricuspid annular velocity were lower than those in the control group across T1-T4 (p < 0.05). Middle cerebral artery peak systolic flow velocities increased across T1-T3 (T1 vs. T2, p < 0.05; T1 vs. T3, p < 0.05; T1 vs. T4, p < 0.05).

conclusionIrrespective of HIE severity, left cardiac output reduced but consistently increased over time in neonates with HIE who required TH. The trend of CBFV gradually increased throughout the TH and rewarming phase. WHAT IS KNOWN: • TH is the standard neuroprotective treatment for moderate-to-severe neonatal HIE, yet survivors continue to face significant neurological sequelae. • Hypoxic-ischemic injury often leads to myocardial dysfunction, and TH itself induces hemodynamic alterations; however, the dynamic evolution of cardiac function and cerebral hemodynamics in neonates with HIE during TH has not been fully elucidated. WHAT IS NEW: • This study demonstrates that, regardless of HIE severity, left cardiac output decreases initially during TH but consistently recovers over time, and biventricular longitudinal systolic function does not deteriorate during the hypothermia phase. • We further observed a gradual increase in CBFV throughout both TH and rewarming. Additionally, even when using Google Chrome, it was not possible to create line breaks during the editing process while adding this section. I sincerely apologize for any formatting issues this may have caused.

Indexed as

HemodynamicsHypothermia, InducedHypoxia-Ischemia, BrainBlood Flow VelocityCase-Control StudiesCerebrovascular CirculationFemaleHumansInfant, NewbornMaleProspective StudiesCardiac functionEchocardiographyHypoxic-ischemic encephalopathyNeonateTherapeutic hypothermia

Identifiers

PMID41559489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.