Evidence map›Paper›PMID 41559454›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain-induced depression in male mice.

Sarah H Journée, Victor P Mathis, Robin Waegaert, Sebahat Ozkan, Enora Langlois, Pilar Ortiz-Teba, Beyza Ayazgok, Léa J Becker, Mithil Gaikwad, Michel Barrot and 4 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah H Journée *Université de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0002-7041-3762
Victor P Mathis *Université de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Robin WaegaertUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Sebahat OzkanUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Enora LangloisUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Pilar Ortiz-TebaLaboratory of Engineering, Informatics and Imaging (ICube), Integrative multimodal imaging in healthcare (IMIS), CNRS, UMR 7357, University of Strasbourg, Strasbourg, France.
Beyza AyazgokUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Léa J BeckerUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Mithil GaikwadUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0003-2387-8695
Michel BarrotUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Sylvain HugelUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0003-2464-3601
Laura HarsanLaboratory of Engineering, Informatics and Imaging (ICube), Integrative multimodal imaging in healthcare (IMIS), CNRS, UMR 7357, University of Strasbourg, Strasbourg, France.
Pierre-Eric LutzUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.ORCID http://orcid.org/0000-0003-3383-1604
Ipek YalcinUniversité de Strasbourg, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France. yalcin@unistra.fr.ORCID http://orcid.org/0000-0003-2596-8598

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-18-CE19-0006-03Agence Nationale de la Recherche (French National Research Agency) ANR-18-CE37-0004Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE37-0010EC | EU Framework Programme for Research and Innovation H2020 | H2020 European Institute of Innovation and Technology (H2020 The European Institute of Innovation and Technology) Marie Sklodowska-Curie grant agreement N°955684Hacettepe Üniversitesi (Hacettepe University) TBI-2018-17569
6 · The paper itself

Abstract

Chronic pain induces long-lasting changes in the anterior cingulate cortex (ACC) activity that contribute to the development of comorbid mood disorders. However, how such alterations propagate throughout the ACC connectome remains to be elucidated. Here, we aimed to study the role of the ACC neurons projecting to the lateral habenula (LHb) (ACC

Indexed as

Chronic PainDepressionGyrus CinguliHabenulaAnimalsCalciumConnectomeDisease Models, AnimalMaleMiceNeural PathwaysNeuronsOptogeneticsSphingolipidsCalciumSphingolipids

Identifiers

PMID41559454
PMCPMC13212962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.