Evidence map›Paper›PMID 41559453›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [

Nakul R Raval, Katina C Calakos, Ming-Qiang Zheng, Anita Huttner, Irina Esterlis, Henry Huang, Vince D Calhoun, Marina R Picciotto, Kelly P Cosgrove, Ansel T Hillmer

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nakul R RavalDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA. nakul.raval@yale.edu.ORCID http://orcid.org/0000-0001-5637-7219
Katina C CalakosDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3872-4210
Ming-Qiang ZhengDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Anita HuttnerDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Irina EsterlisDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6293-1458
Henry HuangDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9058-0747
Marina R PicciottoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4404-1280
Kelly P CosgroveYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1351-9576
Ansel T HillmerDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA. hillmera@med.umich.edu.ORCID http://orcid.org/0000-0002-8105-1381

Funding

Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of SweetenersU54DA036151 · NIDA · YALE UNIVERSITY · PI Meghan E Morean · 2018 to 2026
$41.6M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI Jaime Grutzendler · 2020 to 2026
$30.2M
Imaging Molecular Mechanisms of Tobacco Smoking WithdrawalR01DA038832 · NIDA · YALE UNIVERSITY · PI COSGROVE, KELLY P. · 2016 to 2021
$3.6M
Anatomical Basis for Nicotine AddictionR37DA014241 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2020 to 2026
$2.7M
Novel GluN2BR Radioligand for PET Neuroimaging in Alcohol Use DisorderK99AA032043 · NIAAA · YALE UNIVERSITY · PI Nakul Ravi Raval · 2025 to 2026
$305k
NIAAA NIH HHS K99 AA032043NIA NIH HHS P30 AG066508NIDA NIH HHS R01 DA038832NIDA NIH HHS R37 DA014241NIDA NIH HHS U54 DA036151
6 · The paper itself

Abstract

Tobacco smoking, a major cause of preventable mortality, upregulates β2 subunit-containing nicotinic acetylcholine receptors (β2*-nAChR) in most brain regions. Although the α4 subunit most frequently co-assembles with β2, other subunits likely assemble with β2 and contribute to distinct aspects of nicotine-mediated behaviors, but these factors are poorly understood in people. This work performed independent component analysis (ICA) of [

Indexed as

BrainReceptors, NicotinicSmoking CessationTobacco SmokingAdultBenzamidesBridged Bicyclo Compounds, HeterocyclicFemaleFluorine RadioisotopesHumansMaleMiddle AgedPositron-Emission TomographyBenzamidesBridged Bicyclo Compounds, HeterocyclicFluorine RadioisotopesfluoronorchloroepibatidineReceptors, Nicotinic

Identifiers

PMID41559453
PMCPMC13213061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.