Evidence map›Paper›PMID 41559430›Full record

ArticleInfection2026

Nationwide survey on penicillin allergy delabeling among German healthcare professionals: knowledge, attitudes and perceived barriers.

Insa Joost, Lukas Tometten, Joanne Barry, Alexandra Weber, Till Koch, Hannah Nuernberg, Anne Moeser, Anette Friedrichs, Barbara Eirmbter, Annette Hennigs and 1 more

Abstract read
In one paragraph

Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Insa JoostDepartment of Medical Microbiology and Hospital Hygiene, Duesseldorf University Hospital, Duesseldorf, Germany. insa.joost@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0003-3162-920X
Lukas TomettenDepartment I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Joanne BarryDepartment of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Alexandra WeberAntibiotic Stewardship Team and Department of Pharmacy, University Hospital, LMU Munich, Munich, Germany.
Till Koch3rd Medical Clinic for Pneumology, Infectious Diseases and Oncology, Klinikum Itzehoe, Itzehoe, Germany.
Hannah NuernbergDepartment of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Anne MoeserInstitute of Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.
Anette FriedrichsDepartment of Internal Medicine I, Infectious Diseases, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Barbara EirmbterDepartment of Pharmacy, Duesseldorf University Hospital, Duesseldorf, Germany.
Annette HennigsDivision of Infectious Diseases, Albertinen Heart and Vascular Center, Hamburg, Germany.
Elham KhatamzasDepartment of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePenicillin allergy (PA) delabeling optimizes antibiotic prescribing and is a recognized antimicrobial stewardship (AMS) tool. We aimed to characterize current practices and knowledge of PA delabeling in German non-allergist healthcare professionals to define barriers and facilitators for a wider implementation of delabeling strategies.

methodsA nationwide web-based, anonymous survey was distributed to physicians and hospital pharmacists. It covered four domains: demographics, access to AMS, allergy assessment and attitude towards PA delabeling. Responses were analysed using descriptive and inferential statistics.

resultsA total of 504 responses (249 physicians, 255 pharmacists) were analysed. While 86% of respondents were familiar with the concept of delabeling, only 32% had ever performed it, mostly fewer than 6 times in the past year. 12% of physicians regularly took extended allergy histories, and just 2% always used a standardized method. Only ~ 30% of respondents had onsite access to allergy services. Barriers included lack of time, experience and guidance. Pharmacists frequently cited PA management as outside their role. Despite limited experience, 88% of physicians and 71% of pharmacists expressed interest in delabeling if supported by clear algorithms and institutional support.

conclusionPA delabeling by non-allergists is of great relevance to physicians and pharmacists in Germany but not routinely integrated in clinical pathways, due to missing guidelines, limited resources and unclear role definitions. However, the results of this study highlight the considerable strong potential for implementing structured delabeling strategies-if they are supported by adequate training, clear protocols and sufficiently resourced antimicrobial stewardship teams.

Indexed as

Anti-Bacterial AgentsAttitude of Health PersonnelDrug HypersensitivityHealth Knowledge, Attitudes, PracticeHealth PersonnelPenicillinsAdultAntimicrobial StewardshipFemaleGermanyHumansMaleMiddle AgedPharmacistsPhysiciansSurveys and QuestionnairesAnti-Bacterial AgentsPenicillinsAntimicrobial stewardshipImplementation barriersPenicillin Allergy Delabeling

Identifiers

PMID41559430
PMCPMC13021739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.