Evidence map›Paper›PMID 41559330›Full record

ArticleScientific reports2026

Comparative genomics of colistin-nonsusceptible multidrug-resistant Pseudomonas aeruginosa reveals emerging lineages in Thailand.

Natnicha Wankaew, Tantip Arigul, Worarat Kruasuwan, Piroon Jenjaroenpun, Thidathip Wongsurawat, Teerasak E-Kobon, Aekkawat Unahalekhaka, Phatcharin Laosena, Jiraphan Premsuriya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natnicha WankaewDivision of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tantip ArigulDivision of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Worarat KruasuwanDivision of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Piroon JenjaroenpunDivision of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Thidathip WongsurawatDivision of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Teerasak E-KobonDepartment of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Aekkawat UnahalekhakaDepartment of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Phatcharin LaosenaProgram in Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand.
Jiraphan PremsuriyaPrincess Srisavangavadhana Faculty of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand. jiraphan.pre@cra.ac.th.

Funding

Chulabhorn Royal Academy PSCM2566/001National Research Council of Thailand N42A660897
6 · The paper itself

Abstract

Pseudomonas aeruginosa is a leading cause of multidrug-resistant (MDR) infections, for which the polymyxin antibiotic colistin has been a treatment of last resort. The emergence of colistin-nonsusceptible strains thus poses a serious therapeutic challenge. In this study, we performed whole-genome sequencing and comparative genomic analysis of 29 colistin-nonsusceptible MDR P. aeruginosa clinical isolates collected from hospitals across Thailand between 2021 and 2022. The genomic analysis identified nine distinct sequence types (STs), including a previously uncharacterized ST (ST5340) closely related to the high-risk international clone ST357. This novel ST was the most prevalent (24%) and all of its isolates exhibited resistance to all tested antibiotics. Comprehensive resistome profiling revealed widespread possession of resistance determinants, including multiple beta-lactamases (e.g., bla

Indexed as

Anti-Bacterial AgentsColistinDrug Resistance, Multiple, BacterialPseudomonas aeruginosaPseudomonas Infectionsbeta-LactamasesGenome, BacterialGenomicsHumansMicrobial Sensitivity TestsPhylogenyPolymorphism, Single NucleotideThailandWhole Genome SequencingAnti-Bacterial Agentsbeta-LactamasesColistinColistin-nonsusceptibleGenomic surveillanceHigh-risk cloneMultidrug resistancePseudomonas aeruginosa

Identifiers

PMID41559330
PMCPMC12901977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.