SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Prognostic value of vestibular-evoked myogenic potentials for disease progression and treatment response in Ménière's disease and endolymphatic hydrops: a systematic review.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
purposeTo evaluate the prognostic and treatment-response value of vestibular-evoked myogenic potentials (VEMPs) in adults with Ménière's disease (MD).
methodsA systematic search of MEDLINE, EMBASE, Scopus, and Cochrane Central up to September 2025 was conducted. Longitudinal studies including adults with definite or probable MD, reporting baseline VEMP testing and clinical outcomes (hearing, vertigo, disease progression, or treatment response) were included. Both cervical (cVEMP) and ocular (oVEMP) modalities, including multifrequency protocols, were analyzed. Study quality was assessed using the French version of Newcastle-Ottawa Scale.
resultsAmong the initial 415 articles identified, 34 met our inclusion criteria, including 2,422 patients. Abnormal VEMP parameters, including elevated thresholds, increased interaural amplitude ratios, Inter-Frequency Amplitude Ratio, and absent responses, correlated with advanced disease stage, hearing deterioration, vertigo severity, and progression to definite or bilateral MD. VEMP changes were frequently observed following intratympanic gentamicin and select surgical interventions, reflecting treatment response. Multifrequency VEMPs enhanced detection of subclinical otolithic dysfunction and differentiation of active versus stable disease.
conclusionVEMPs provide a reliable functional biomarker of vestibular involvement, disease progression, and treatment response in MD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.