ArticleScientific reports2026
Carbon Dots and mesoporous silica nanocomposites improve spray-induced gene silencing to suppress plant RNA and DNA viruses.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Nanoparticle-enhanced multi-target RNAi in Myzus persicae: Molecular mechanisms, cross-kingdom sRNA transfer, and efficacy for sustainable pest management.Pest management science · 2026Article
- RNAi: the next wave of green agriculture, challenges, and bridging the translational gap.Plant cell reports · 2026Review
- The unfulfilled potential of nanocarriers for RNA delivery in antiviral crop protection.Nature plants · 2026Review
- Nano-enabled plant genetic engineering for stress resilience: current advances and future directions.Frontiers in plant science · 2026Review
- Spray-induced gene silencing for plant disease control: mechanistic basis and deployment-oriented design.Frontiers in plant science · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The management of emerging plant viruses presents significant challenges for global agriculture, requiring innovative approaches beyond conventional control strategies. Traditional methods rely on cultural practices, vector management, and breeding for genetic resistance, and these approaches are often time-consuming and may have limited effectiveness against emerging viral strains. Spray-Induced Gene Silencing (SIGS), involving topical application of virus-derived double-stranded RNA (dsRNA) to trigger plant defense mechanisms, offers a promising alternative strategy. However, the application of SIGS faces challenges due to inefficient dsRNA uptake by the plant, among other issues. In this study, we developed and characterized nanocomposite formulations using carbon dots (CDs) and polyethylenimine-functionalized mesoporous silica nanoparticles (PMSNs) to enhance dsRNA delivery and stability for the control of turnip mosaic virus (TuMV) and beet curly top virus (BCTV), an RNA and a DNA virus, respectively, in Nicotiana benthamiana. Our results demonstrated that dsRNA delivery was significantly enhanced (up to 5-fold) when formulated with nanoparticles compared to naked dsRNA. For TuMV-infected plants, both nanocomposite formulations significantly reduced viral titers (by 13.5-fold for PMSNs and 17.3-fold for CDs) and maintained photosynthetic capacity similar to uninfected controls even at 66 days post-inoculation. Regarding BCTV, the nanocomposite treatments significantly delayed disease symptom appearance and reduced viral DNA accumulation by 8-28-fold compared to control plants. The enhanced antiviral efficacy observed with nanoparticle formulations correlates with improved dsRNA delivery and persistence in plant tissues, making the nanoparticle-based dsRNA delivery systems represent a viable approach for developing sustainable, environmentally friendly strategies to protect crops against economically important viral diseases.
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Registered trials
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