Evidence map›Paper›PMID 41559234›Full record

ArticleMikrochimica acta2026

Polyvinylpyrrolidone-modified iron single-atom nanozymes: preparation and application to highly sensitive immunomagnetic bead assay for tetracycline detection.

Li Wang, Qingwen Dong, Lixin Xu, Wuyang Huang, Hui Meng, Mingming Wang, Kun Zeng, Zhen Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li WangSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.
Qingwen DongSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.
Lixin XuSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.
Wuyang HuangSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.
Hui MengSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.
Mingming WangSuqian Water Conservancy Bureau, No. 4, Renmin Avenue, Suqian, 223800, China.
Kun ZengSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China. kjj80116@ujs.edu.cn.
Zhen ZhangSchool of the Environment and Safety Engineering, School of the Emergency Management, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China. zhangzhen@ujs.edu.cn.

Funding

Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Drug Efficacy and Health Risk Assessment Key Laboratory of Zhenjiang SS2024006Science and Technology Innovation Fund in Zhenjiang City SH2024063
6 · The paper itself

Abstract

A one-pot method was adopted to prepare polyvinylpyrrolidone (PVP)-modified iron single-atom nanozymes (FeSANs) as signal amplification probes, establishing a rapid and sensitive immunomagnetic bead assay (IMBA) for tetracycline (TC) detection. After optimization, Fe10-ZIF-8@PVP demonstrated the highest oxidase-like and peroxidase-like activities in comparison with Fe5-ZIF-8@PVP, Fe20-ZIF-8@PVP, and Fe10-ZIF-8. The Michaelis-Menten constants (Km) for the substrates 3,3’,5,5’-tetramethylbenzidine (TMB) and hydrogen peroxide (H₂O₂) were measured as 0.31 mM and 0.67 mM, respectively. The Fe10-ZIF-8@PVP-assisted IMBAs demonstrated the highest sensitivity, achieving a limit of detection (LOD) as low as 0.196 ng/mL, The sensitivity was enhanced by 48-fold compared to conventional ELISA. Furthermore, the Fe10-ZIF-8@PVP-based IMBA was successfully applied to analyze honey, milk, water and soil samples, yielding recoveries of 97.3% to 109.3%, 92.5% to 105.6%, 89.1% to 108.5% and 93.5% to 107.8%, respectively. Practical analysis of environmental samples revealed TC residues not exceeding regulatory limits, with concentrations above the detection limit found only in three of 32 samples analzed (i.e. 0.43 ng/ml, 1.24 ng/ml, and 0.36 ng/ml in one of the honey, milk and water samples, respectively). This method offers a highly sensitive, rapid, and cost-effective alternative to conventional ELISA for antibiotic detection in food safety.

Indexed as

Anti-Bacterial AgentsImmunomagnetic SeparationIronPovidoneTetracyclineAnimalsHoneyHydrogen PeroxideLimit of DetectionMilkAnti-Bacterial AgentsHydrogen PeroxideIronPovidoneTetracyclineImmunomagnetic beadNanozymePeroxidase-likeTetracycline detection

Identifiers

PMID41559234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.