Evidence map›Paper›PMID 41559201›Full record

ArticleThe EMBO journal2026

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells.

Yonas M Tesfamariam, Maria H Christensen, Stefan Diehl, Tabea Klein, Julius M Lingnau, Sabine Normann, Elena Hagelauer, Miriam Herbert, Sophie Reimer, Richa P Joshi and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yonas M TesfamariamInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-0106-7277
Maria H ChristensenInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-4778-3009
Stefan DiehlInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-8058-7897
Tabea KleinInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Julius M LingnauInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Sabine NormannInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Elena HagelauerInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Miriam HerbertInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-8732-4766
Sophie ReimerInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Richa P JoshiInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Pujan EngelsInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Steffen PritzlInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Pietro FontanaDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0003-3215-3784
Thomas ZillingerInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-0866-4835
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Anna Eis-HübingerInstitute of Virology, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Martin C LamDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0002-4073-7379
Klaus J WalgenbachDivision of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.
Felix MeissnerInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany.ORCID http://orcid.org/0000-0003-1000-7989
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Florian I SchmidtInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127, Bonn, Germany. fschmidt@uni-bonn.de.ORCID http://orcid.org/0000-0002-9979-9769

Funding

Boehringer Ingelheim Stiftung (Boehringer Ingelheim Foundation) Rise Up!Deutsche Forschungsgemeinschaft (DFG) Emmy Noether Programme 322568668Deutsche Forschungsgemeinschaft (DFG) Germany's Excellence Strategy - EXC2151-390873048Deutsche Forschungsgemeinschaft (DFG) TRR237-369799452
6 · The paper itself

Abstract

The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investigate inflammasome responses in human primary cells, we used engineered viruses encoding the inflammasome reporter caspase-1

Indexed as

DNA-Binding ProteinsDNA, ViralGenome, ViralInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPoxviridaeAnimalsCells, CulturedHumansInnate Immunity RecognitionMacrophagesMiceVaccinia virusAIM2 protein, humanDNA-Binding ProteinsDNA, ViralInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanAIM2InflammasomeNanobodyNLRP3Poxvirus

Identifiers

PMID41559201
PMCPMC12953764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.