Evidence map›Paper›PMID 41559199›Full record

ArticleClinical neuroradiology2026

Time-intensity Profiles and T1-corrected Arterial Transit Time from Multi-delay Pseudo-continuous ASL with a Variable-TR Scheme for the Characterization of Adult-type Diffuse Glioma.

Koji Yamashita, Makoto Obara, Kazufumi Kikuchi, Ryoji Mikayama, Daichi Momosaka, Masaoki Kusunoki, Daisuke Kuga, Ryusuke Hatae, Yutaka Fujioka, Ryosuke Otsuji and 6 more

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Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Koji YamashitaDepartment of Molecular and Imaging Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. yamashita.koji.659@m.kyushu-u.ac.jp.
Makoto ObaraPhilips Japan, Tokyo, Japan.
Kazufumi KikuchiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryoji MikayamaDepartment of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.
Daichi MomosakaDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masaoki KusunokiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Daisuke KugaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryusuke HataeDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yutaka FujiokaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryosuke OtsujiDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tatsuhiro WadaDepartment of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.
Chiaki TokunagaDepartment of Medical Technology, Kyushu University Hospital, Fukuoka, Japan.
Marc Van CauterenPhilips Japan, Tokyo, Japan.
Osamu TogaoDepartment of Radiology, Faculty of Medicine, Saga University, Saga, Japan.
Koji YoshimotoDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kousei IshigamiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe cerebral blood flow (CBF) measured by multi-delay ASL (4D-ASL) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Dynamic changes in signal intensity (SI) and arterial transit time (ATT) obtained from 4D-ASL may also be key factors in differentiating adult-type diffuse glioma. Furthermore, the longitudinal relaxation time (T1) of brain tumor may influence on CBF and ATT when using ASL techniques. Our purpose was to determine if time-intensity profiles from 4D-ASL using a variable-TR scheme and T1-corrected ATT (ATT MATERIALS AND

methodsThe 4D-ASL with a variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A total of 14 LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATT

resultsThirty patients were included in the study. ATT and the SI peak time in diffuse glioma with IDH-wildtype (IDHw) were significantly shorter than astrocytoma, IDH-mutant (p < 0.01, each). Moreover, ATT

conclusionThe 4D-ASL with a variable-TR scheme includes ATT

Indexed as

Brain NeoplasmsGliomaMagnetic Resonance AngiographyAdultAgedCerebrovascular CirculationFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPerfusion Magnetic Resonance ImagingSensitivity and SpecificityArterial spin Labeling Perfusion weighted ImagingArterial Transit timeGliomaMagnetic Resonance Imaging

Identifiers

PMID41559199

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