Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Haisheng He *Department of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0002-5205-7426
Wenwei Zhu *Department of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-4112-9156
Han MiaoSchool of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
Shangfeng WangDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0003-2247-7558
Zunguo DuDepartment of Pathology of Huashan Hospital, Fudan University, Shanghai, China.
Hongxin ZhangDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0002-1934-2049
Jiang MingDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0002-9375-5730
Ben ShiDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0009-0002-1400-5040
Hao WangDepartment of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China.
Jianping QiDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0003-4833-1426
Yong FanDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0001-5220-9445
Wei WuDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0002-0164-0814
Dongyuan ZhaoDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China.ORCID http://orcid.org/0000-0001-8440-6902
Lun-Xiu QinDepartment of General Surgery, Hepatobiliary Surgery Center, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China. qinlx@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4805-8239
Fan ZhangDepartment of Chemistry, College of Smart Materials and Future Energy, School of Pharmaceutical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Molecular Engineering of Polymers and iChem, Key Laboratory of Smart Drug Delivery Ministry of Education and State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Shanghai Wusong Laboratory of Materials Science, Fudan University, Shanghai Academy of Natural Sciences (SANS), Shanghai, China. zhang_fan@fudan.edu.cn.ORCID http://orcid.org/0000-0001-7886-6144
Funding
National Natural Science Foundation of China (National Science Foundation of China) 82104082Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 21QA1406700, 22JC1400400, 24Y12800500Shanghai Municipal Education Commission 2023ZKZD08
6 · The paper itself
Abstract
Successful surgical resection of solid tumours requires highly reliable real-time intraoperative tools to accurately delineate tumour boundaries, which remains challenging in routine clinical standards. Here, we identify endogenous substances with intense autofluorescence in the second near-infrared window (NIR-II, 1,000-1,700 nm) that are abundant in human liver tissues but negligible in cancerous tissues. Inspired by this discovery, we develop a label-free and wide-field imaging approach, named tissue autofluorescence NIR-II imaging (TANI) for visualizing human liver malignancies. TANI demonstrates exceptional contrast (7.69 ± 0.52), sensitivity (97.8%) and specificity (98.4%) in delineating various liver malignancies, including hepatocellular carcinoma, intrahepatic cholangiocarcinoma and liver metastasis from cirrhotic or non-cirrhotic livers, outperforming routine fluorescence-guided surgery and conventional autofluorescence imaging in the visible (400-650 nm) or first near-infrared (700-900 nm) window. The excellent performance of TANI remains unaffected by cancer grade/stage, benign lesions or blood/bile contamination. These findings represent a promising advance in intraoperative decision-making and suggest a strong correlation between near-infrared autofluorescence and diseases. We believe that clarifying the molecular insights underlying these autofluorescent substances may provide new diagnostic directions.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Label-free tissue NIR-II autofluorescence imaging for visualization of human liver malignancy. · full record | OpenQuestion