Evidence map›Paper›PMID 41559186›Full record

SynthesisScientific reports2026

Surgical resection versus non-surgical treatments for hepatocellular carcinoma with macrovascular invasion.

Yifeng Fang, Enjie Zhou, Jiahao Hu, Bin Zhang, Jiliang Shen, Tuck-Whye Wong, Yifan Wang, Shuyou Peng, Jiasheng Cao

Abstract readMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yifeng Fang *Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Enjie Zhou *Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Jiahao HuDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Bin ZhangDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Jiliang ShenDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Tuck-Whye WongDepartment of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, Skudai, 81300, Johor, Malaysia.
Yifan WangDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Shuyou PengDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China.
Jiasheng CaoDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou, 310016, Zhejiang Province, China. blackcao@zju.edu.cn.

Funding

Medical and Health Science and Technology Program of Zhejiang Province 2024KY1139Natural Science Foundation of Zhejiang Province LQ23H160036
6 · The paper itself

Abstract

The optimal treatment strategy for hepatocellular carcinoma (HCC) with macrovascular invasion (MaVI) remains unclear. The study aimed to compare the survival outcomes between surgical resection (SR) and non-surgical resection (non-SR) treatments for HCC patients with MaVI. We conducted systematic search for relevant studies from January 1990 to July 2023. Two levels of subgroup analyses were conducted based on tumor thrombosis types and treatment modalities in non-SR group. A cumulative meta-analysis was performed and sensitivity analysis assessed the robustness of the results. Begg's test, Egger's test, and funnel plots were used to identify publication bias. The meta-analysis included 33 studies with 10,551 patients (SR, n = 4,903 vs. non-SR, n = 5,648). The 1-year (RR = 1.51, 95% CI:1.36-1.68, I

Indexed as

Carcinoma, HepatocellularHepatectomyLiver NeoplasmsHumansNeoplasm InvasivenessTreatment OutcomeHepatocellular carcinomaMacrovascular invasionNon-surgical treatmentsOverall survivalSurgical resection

Identifiers

PMID41559186
PMCPMC12894676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.