Retinal structure and function recovery over five years in Vogt-Koyanagi-Harada disease using adaptive optics and microperimetry.

Tomoko Nakamura, Shinya Abe, Toshihiko Oiwake, Atsushi Hayashi

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tomoko NakamuraDepartment of Ophthalmology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. nakatomo@med.u-toyama.ac.jp.

Shinya AbeDepartment of Ophthalmology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Toshihiko OiwakeDepartment of Ophthalmology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Atsushi HayashiDepartment of Ophthalmology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Funding

Japan Society for the Promotion of Science JP24K19785

6 · The paper itself

Abstract

Vogt-Koyanagi-Harada (VKH) disease recovery patterns remain inadequately characterized over extended periods. This study evaluated retinal changes in VKH patients across 5 years using adaptive optics imaging and microperimetry. Twenty-five eyes from 13 patients were monitored longitudinally. Macular cone density gradually increased throughout the observation period but remained below healthy control levels. Eyes with pretreatment cystoid spaces initially showed lower cone density values, but this disparity disappeared after 3 years. Average threshold values improved consistently from baseline, while macular integrity values significantly decreased after 2 years. Cone density correlated significantly with retinal sensitivity. These findings indicate that with appropriate treatment, VKH disease demonstrates progressive improvement in both retinal structure and function over time, though complete structural recovery may not occur. Pretreatment cystoid spaces influence early outcomes but do not significantly affect long-term recovery.

Indexed as

Recovery of FunctionRetinaUveomeningoencephalitic SyndromeAdultFemaleHumansMaleMiddle AgedRetinal Cone Photoreceptor CellsTomography, Optical CoherenceVisual AcuityVisual Field TestsAdaptive opticsCone densityMicroperimetryPhotoreceptorRetinal sensitivityVogt-Koyanagi-Harada disease

Identifiers

PMID41559144

DOI10.1038/s41598-025-34652-6

PMCPMC12868689

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.