Evidence map›Paper›PMID 41559064›Full record

ArticleNPJ Parkinson's disease2026

Sleep firing rate homeostasis is disrupted in mild parkinsonism.

Bharadwaj Nandakumar, Ajay K Verma, Ying Yu, Ethan Marshall, Adele L DeNicola, Jing Wang, Colum D MacKinnon, Michael J Howell, Jerrold L Vitek, Luke A Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bharadwaj Nandakumar *Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Ajay K Verma *Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Ying YuDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Ethan MarshallDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Adele L DeNicolaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael J HowellDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA. joh03032@umn.edu.

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Optimizing coordinated reset deep brain stimulation for Parkinson's diseaseR01NS117822 · NINDS · UNIVERSITY OF MINNESOTA · PI WANG, JING · 2020 to 2024
$3.0M
Sleep-specific DBS therapy in Parkinson's diseaseR01NS131371 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2023 to 2026
$2.4M
NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01-NS058945NINDS NIH HHS R01 NS110613NINDS NIH HHS R01-NS110613NINDS NIH HHS R01 NS117822NINDS NIH HHS R01NS117822NINDS NIH HHS R01 NS131371NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

Reduction in neuronal firing from wake to sleep, i.e., sleep firing rate homeostasis (sFRH), is essential for restorative sleep. Sleep dysfunction is common in Parkinson's disease (PD), but sFRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical sFRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored to normalize sFRH and reestablish restorative sleep in PD.

Identifiers

PMID41559064
PMCPMC12886782

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.