Evidence map›Paper›PMID 41558800›Full record

Observational studyBMJ open respiratory research2026

Comprehensive characterisation of individuals with fibrotic interstitial lung disease: baseline insights from the INJUSTIS study.

Fasihul Khan, Iain Stewart, Lucy Howard, Christopher Michael Barber, Rebecca Borton, Rebecca Braybrooke, Glenn Hearson, Steve Jones, Toby Maher, Laura Matthews and 5 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03670576 (It's Not JUST Idiopathic Pulmonary Fibrosis Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03670576 unknown statusnot on this map

It's Not JUST Idiopathic Pulmonary Fibrosis Study

TypeobservationalSponsorUniversity of NottinghamRan2018 to 2022Enrolled250ConditionsInterstitial Lung Disease, Idiopathic Pulmonary FibrosisArmsOptional Bronchoscopy, Quality of Life Questionnaires, Blood Samples for Biomarkers, Home Hand Held Spirometry
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fasihul KhanRespiratory Medicine, University of Nottingham, Nottingham, UK fasihul.khan1@nhs.net.ORCID http://orcid.org/0000-0002-0796-5724
Iain StewartNational Heart & Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1340-2688
Lucy HowardAdelphi Real World, Bollington, UK.
Christopher Michael BarberRespiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.ORCID http://orcid.org/0000-0003-2234-4165
Rebecca BortonPatientmpower Ltd, Dublin, UK.ORCID http://orcid.org/0000-0002-2292-4103
Rebecca BraybrookeRespiratory Medicine, University of Nottingham, Nottingham, UK.
Glenn HearsonRespiratory Medicine, University of Nottingham, Nottingham, UK.
Steve JonesAction for Pulmonary Fibrosis, Peterborough, UK.
Toby MaherUSC Keck School of Medicine, Los Angeles, California, USA.
Laura MatthewsRespiratory Medicine, University of Nottingham, Nottingham, UK.
Gauri SainiRespiratory Medicine, University of Nottingham, Nottingham, UK.
Norma ThompsonRespiratory Medicine, Nottingham Respiratory Research Unit, Nottingham, UK.
Andrew M WilsonNorwich Medical School, University of East Anglia, Norwich, UK.
Simon R JohnsonRespiratory Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-9837-2763
Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7929-2119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterstitial lung disease (ILD) represents a group of complex parenchymal conditions characterised by varying clinical trajectories. The It's Not JUST Idiopathic Pulmonary Fibrosis Study seeks to identify genetic, proteomic and clinical biomarkers that distinguish rapidly progressive fibrotic phenotypes from stable phenotypes irrespective of aetiology. This manuscript presents baseline insights from the recruited cohort.

methodsIn this prospective, longitudinal study, participants with fibrotic ILDs, including idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis, rheumatoid arthritis-associated ILD, asbestosis and unclassifiable ILD, were enrolled from 24 UK sites. Participants underwent comprehensive baseline evaluation including demographics, exposure history, lung function testing, 6-min walk tests, blood sampling and standardised questionnaires to assess symptoms and quality of life.

resultsA total of 272 participants were recruited, predominantly older white males with a smoking history. Baseline lung function showed comparable forced vital capacity (mean 89.0% predicted), diffusion of carbon monoxide (mean 57.9% predicted) and 6-min walk distance (mean 302 m) across ILD subtypes. Hypertension was the most prevalent comorbidity, affecting 40.8% of participants, with no significant differences across subtypes. Anxiety and depression were notably lower in IPF than non-IPF (4.5%; 21.0%). Previous occupational exposure was reported in 68.8% of participants, with asbestos exposure the most prevalent (36%). Bird exposure was reported by 40.4% of participants, with no significant differences across subtypes. No significant differences in health-related quality of life scores were observed across subtypes.

conclusionsDespite varied aetiologies, fibrotic ILDs exhibit demographic and functional similarities, including lung function and health-related quality of life suggesting commonalities in disease mechanisms. TRIAL REGISTRATION NUMBER: NCT03670576.

Indexed as

Idiopathic Pulmonary FibrosisLung Diseases, InterstitialAgedAlveolitis, Extrinsic AllergicArthritis, RheumatoidAsbestosisFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesQuality of LifeRespiratory Function TestsUnited KingdomVital CapacityIdiopathic Pulmonary FibrosisInterstitial Fibrosis

Identifiers

PMID41558800
PMCPMC12820847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.